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fMRI Accelerated TMS Depression

Tracking Brain Imaging Changes in Depression Over Clinical Accelerated Transcranial Magnetic Stimulation (TMS) Therapy at the Individual Level

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 65 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Visits mentioned: 2 visits
  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "The aim of this study is to use magnetic resonance imaging (MRI) to capture images of participants' brains and apply an image processing method called INSCAPE to assess brain states."
  • "Participation in this study involves two visits, each including a 30-minute MRI scan."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether a new way to study brain scans, called INSCAPE, can track brain recovery during a faster course of depression treatment. It is for adults with major depressive disorder who receive TMS, a treatment that uses magnetic pulses to stimulate the brain.

This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pattern Estimation") neuroimaging method in Major Depressive Disorder (MDD) patients can track brain recovery of MDD patients over an accelerated antidepressant transcranial magnetic stimulation (TMS) treatment.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Are 18 to 65 years old.
  • Can give your own consent in English and sign the study consent form.
  • Have major depressive disorder diagnosed using DSM-IV guidelines.

Who can't join

  • Cannot speak English.
  • Cannot safely have an MRI scan, or have metal devices implanted in your head, heart, or neck.
  • Have any current or recent untreated health, brain, nerve, or mental health condition, or have another mental health, brain, nerve, or personality disorder.
  • Have had brain surgery, a head injury, or a concussion, or report a moderate to severe brain injury.
  • Have used cortisol medicine or had electroconvulsive therapy, a treatment that uses electrical currents to cause a brief seizure.
  • Have had a heart attack, an irregular heartbeat, or a slow heartbeat.
  • Have frequent or severe headaches, or a moderate to severe alcohol or drug use disorder.
  • Are pregnant.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Age 18-65 * Have the capacity and ability to provide one's own consent in English and sign the informed consent document. * DSM-IV diagnosis of MDD Exclusion Criteria: * Unable to speak English. * Contraindicated for MRI. * Any current or recent untreated medical, neurological, or psychiatric conditions * Metal implant devices in the head, heart, or neck. * History of brain surgery. * History of cortisol medication use or electroconvulsive therapy. * Comorbidity with other psychiatric/neurological illnesses or personality disorders * History of myocardial infarction or arrhythmia, bradycardia. * Personal history of head injury, concussion, or self-report of moderate to severe traumatic brain injury. * Individuals suffering from frequent/severe headaches. * Moderate to severe alcohol or substance use disorder. * Pregnancy

Study sites (1)

SC