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Growth Hormone Resistance of Beta-cells A

Growth Hormone Resistance of Beta-cells in Women With Gestational Diabetes Mellitus

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 45 Years
Sex
Female only
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how growth hormone affects beta-cells, the cells in the pancreas that make insulin and help control blood sugar. It is for people who had a full-term pregnancy with one baby in the past 5 years, with or without diabetes during pregnancy.

The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Had a full-term pregnancy with one baby within the past 5 years.
  • Have a body mass index (BMI), a measure of weight compared to height, of at least 18.5 but less than 45.
  • For the gestational diabetes group: had diabetes during the most recent pregnancy.
  • For the comparison group: have never had diabetes during pregnancy.

Who can't join

  • Are pregnant, plan to become pregnant during the study, or are breastfeeding.
  • Have or have ever had type 1 or type 2 diabetes, or have a parent, sibling, or child with diabetes.
  • Take medicines that could affect study results, such as GLP-1 medicines; have had weight-loss surgery; or have a known, uncontrolled underactive thyroid.
  • Have a history of high pressure inside the skull, including swelling of the nerve at the back of the eye, or a condition that raises this risk, such as Turner syndrome, Prader-Willi syndrome, or poor kidney function.
  • Have cancer now or have been in remission for less than 5 years; have serious anemia (too few healthy red blood cells); or have serious organ problems, such as liver, kidney, or heart disease.
  • Have an alcohol use disorder, use controlled substances, or smoke more than 2 cigarettes a day.
  • Lost more than 3% of your weight in the 3 months before screening, or regularly do moderate or hard exercise for at least 30 minutes without stopping on 3 or more days a week.
  • Have a mental disability, are a prisoner, or cannot freely give informed consent to join the study.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Singleton, full term pregnancy within the past 5 years * Body mass index ≥18.5 kg/m2 and \<45.0 kg/m2 Group specific inclusion criteria: * Gestational Diabetes Group: History of gestational diabetes in the most recent pregnancy * Control Group: no history of gestational diabetes Exclusion Criteria: * Pregnant, planning to become pregnant during the study, or breastfeeding * Current diagnosis or history of type 1 or type 2 diabetes * Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists) * History of bariatric surgery * Known, uncontrolled hypothyroidism * History of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment * Current cancer or cancer that has been in remission less than 5 years * First degree relative with diabetes diagnosis * Evidence of significant anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease) * Alcohol use disorder, use of controlled substances, or smoking \>2 cigarettes per day * Greater than 3% weight loss within three months of screening or engaged in regular (≥3 days per week), continuous moderate- or high-intensity exercise of ≥30 min duration * Mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent

Study sites (1)

MO