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Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 100 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study checks how accurate lab tests, equipment, devices, and methods for placing an IV tube in a vein are. It also checks whether repeated tests give the same results. It is for adults who are healthy or have certain hormone, heart, blood sugar, bone, joint, or muscle disorders.

The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research on chronic diseases, nutrition, and metabolism (the process by which a substance is handled in the body) at the University of Missouri. As technology changes and uses new testing methods, it is necessary to compare results from old tests, equipment and devices and new tests, equipment, or devices and the reproducibility of these measurements to make sure the results are accurate. Reproducibility means performing the same test more than once to see if the same results can be achieved each time. This study will look at the validation and reproducibility of tests and laboratory assays in participants who are healthy or affected by relevant endocrine, cardiometabolic, and musculoskeletal disorders.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 18 to 100 years old.
  • Your body mass index (BMI), a measure based on height and weight, is 16 to 60.

Who can't join

  • You are outside the study’s age range of 18 to 100.
  • Your BMI is below 16 or above 60.
  • You have allergies, food intolerances, or diet limits involving study meal ingredients, or you are vegan or vegetarian.
  • You take medicines or supplements that could affect the tests or methods being checked.
  • You do more than 150 minutes of planned exercise each week, unless this is needed for the test being checked.
  • You have a serious disease or organ problem, unless the study needs people with that condition to check a test or method.
  • You have alcohol use disorder (problem drinking) or use controlled substances, unless alcohol use disorder is needed to check the test or method.
  • You are pregnant, smoke, are a prisoner, or cannot freely give informed consent—agreeing to join after understanding the study.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * ≥18 and ≤100 years of age * body mass index ≥16.0 and ≤60 kg/m2 Exclusion Criteria: * \<18 and \>100 years of age * body mass index \<16.0 or \>60 kg/m2 * allergies, intolerances, or dietary restrictions to meal ingredients, vegans or vegetarians * use of medications or dietary supplements (e.g., anti-inflammatories, immune modulators, etc) that could interfere with the particular assay/techniques being evaluated * engaged in regular structured exercise \>150 min per week unless needed for validation of the assay/technique being evaluated * significant organ system dysfunction or diseases, except those that are sought for validation of the assay/technique being evaluated * alcohol use disorder as defined by the National Institute of Alcohol Abuse and Alcoholism or use of controlled substances unless alcohol use disorder is required for validation of the assay/technique being evaluated * pregnant women, persons who smoke, prisoners, and inability to grant voluntary informed consent.

Study sites (1)

MO