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RecruitingPhase 2

Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 65 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests how well iloperidone works and how safe it is for people whose high blood pressure is not controlled by medicine. It compares iloperidone with a placebo, a treatment with no active drug.

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants with Uncontrolled Hypertension

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Your top blood pressure number while sitting is 130 mmHg or higher, even after more than 8 weeks of treatment with at least one blood pressure medicine.

Who can't join

  • You have confirmed severe high blood pressure: a top number while sitting of 180 mmHg or higher, or a bottom number of 120 mmHg or higher.
  • You have heart disease that is not stable.
  • Your kidneys do not work well enough.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * SiSBP \>/= 130 mmHg despite \>8 weeks treatment w/ 1 or more antihypertensive therapies Exclusion Criteria: * Confirmed Grade 3/severe hypertension (SiSBP \>/= 180 mmHg, SiDBP \>/= 120 mmHg), unstable cardiac disease, renal insufficiency

Study sites (28)

AZ

CA

FL

GA

IL

KS

KY

MO

NC

NV

NY

OH

OK

SC

TX

UT

VA