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Effects of Grape Consumption on the Immune-Gut Axis in Obesity

Effects of Grape Consumption on Immune and Gut Health in the Setting of Obesity

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 60 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests how whole freeze-dried grape powder affects the immune system and gut in adults with obesity. It is for adults ages 18–60 who meet the study rules.

This study is investigating the benefits of whole freeze-dried grape powder consumption on the immune-gut axis in adults with obesity.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 18–60 years old.
  • Your BMI is 30–45. BMI is a measure of weight compared with height.
  • You are willing to eat the study foods.
  • Your diet and activity habits have stayed the same for 4 weeks.
  • Your weight has changed by less than 5 kg (about 11 pounds) in the last 3 months.
  • You have not smoked for at least 1 year.
  • You are not currently eating an extremely healthy diet.

Who can't join

  • You are allergic to study foods, or you regularly eat grapes or grape products.
  • You have a stomach or bowel disease, have had weight-loss surgery, have diabetes, or have HIV.
  • You have uncontrolled high blood pressure with a reading above 180/110.
  • You use illegal drugs or have a history of alcohol or drug abuse.
  • You recently used medicines that affect the immune system, such as steroids, or recently started medicines that affect appetite or how your body uses energy.
  • You recently used antibiotics; prebiotics, probiotics, or synbiotics (products that support gut bacteria); or supplements with fiber or plant compounds.
  • You are pregnant or breastfeeding.
  • You take medicines for disease in the arteries of the heart or arms and legs. The source's medicine exclusion list is cut off.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Age: 18-60 years * Obesity with BMI of 30-45 kg/m2 * Willingness to consume study foods * Consistent diet and activity patterns for 4 weeks * Weight stable (\<5kg change over last 3 months) * Non-smoker \> 1 year or more * Not currently consuming an extremely healthy diet Exclusion Criteria: * Study food allergies * Regular consumption of grapes or grape-derived products * Gastrointestinal disease and/or bariatric surgery * Uncontrolled hypertension and blood pressure \>180/110 * Diabetes * Illicit drug use * History of alcohol or drug abuse * Recent use of medications that affect immune function (e.g., corticosteroids) * Recent consumption of antibiotics, prebiotics, probiotics, symbiotics, or dietary supplements containing fiber or phytochemicals * Pregnant or lactating individuals * HIV positivity * Recent start of medications that affect metabolism or appetite * Drug therapy for coronary artery disease, peripheral artery disease, congestive

Study sites (1)

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