A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, and Type 2 Diabetes
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study tests whether eloralintide helps people lose weight and is safe compared with a placebo (a treatment with no active drug). It is for people with overweight or obesity who also have type 2 diabetes. The study lasts about 75 weeks.
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Have type 2 diabetes.
- Have been on stable diabetes treatment for at least 90 days before screening.
- Have a body mass index (BMI) of 27 or higher. BMI is a measure based on height and weight.
- Have had less than a 5% change in body weight during the 90 days before screening.
Who can't join
- Have had or plan to have weight-loss surgery. Liposuction, fat freezing, or a tummy tuck is allowed if done more than 1 year before screening.
- Have had or plan to have a weight-loss procedure using a tube with a camera, or treatment using a weight-loss device. A past device is allowed if removed more than 6 months before screening.
- Have type 1 diabetes.
- Have used insulin or diabetes drugs called amylin analogs, GLP-1 receptor agonists, or GIP/GLP receptor agonists in the 90 days before screening.
- Had a heart attack, stroke, procedure to restore blood flow to the heart, unstable angina (new or worsening heart-related chest pain), or a hospital stay for heart failure in the 90 days before screening.
- Have or have had Class IV heart failure, the most severe class of heart failure.
- Have taken medicines or alternative remedies meant for weight loss within 90 days of screening.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * Have type 2 diabetes * Are on stable treatment for type 2 diabetes for at least 90 days prior to screening * Have a BMI ≥ 27 kg/m2 * Have a stable body weight (\<5% body weight change) for 90 days prior to screening Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes * Have taken any of the following antihyperglycemic medications within 90 days before screening: * amylin analogs * glucagon-like peptide-1 (GLP-1) receptor agonists * glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP) receptor agonists, or * insulin * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure * Have taken medications or alternative remedies intended for weight loss within 90 days of screening
Study sites (60)
AL
- Birmingham Clinical Research · Birmingham, AL 35209 · Study contact · 205-870-4343Nova Law · Principal investigatorMore trials in Birmingham
- Cullman Clinical Trials · Cullman, AL 35055 · Study contact · 256-708-2826Randall Quinn · Principal investigatorMore trials in Cullman
AZ
- Tucson Clinical Research Institute · Tucson, AZ 85712Girish Karamchandani · Principal investigatorMore trials in Tucson
CA
- San Fernando Valley Health Institute · Canoga Park, CA 91304 · Study contact · 818-222-6868Jeffrey London · Principal investigatorMore trials in Canoga Park
- AMCR Institute · Escondido, CA 92025 · Study contact · 760-466-1520Jenine Stone · Principal investigatorMore trials in Escondido
- NorCal Medical Research, Inc · Greenbrae, CA 94904 · Study contact · 415-461-1585Linda Gaudiani · Principal investigatorMore trials in Greenbrae
- Ark Clinical Research · Long Beach, CA 90815Martha Navarro · Principal investigatorMore trials in Long Beach
- Pacific Clinical Studies · Los Alamitos, CA 90720 · Study contact · 562-598-0600 ext 205Etsegenet Ayele · Principal investigatorMore trials in Los Alamitos
- Inglewood Clinical · Los Angeles, CA 90056 · Study contact · 310-693-5000Maricor Grio · Principal investigatorMore trials in Los Angeles
- Care Access - Santa Clarita · Santa Clarita, CA 91321 · Study contact · 661-371-7272Sina Tebi · Principal investigatorMore trials in Santa Clarita
- Encompass Clinical Research · Spring Valley, CA 91978 · Study contact · 619-660-9068Hanid Audish · Principal investigatorMore trials in Spring Valley
- Diablo Clinical Research, Inc. · Walnut Creek, CA 94598 · Study contact · 925-930-7267Bonnie Kimmel · Principal investigatorMore trials in Walnut Creek
CO
- Care Access - Aurora · Aurora, CO 80012 · Study contact · 720-368-4865Mauricio Waintrub · Principal investigatorMore trials in Aurora
CT
- New England Research Associates, LLC · Bridgeport, CT 06606 · Study contact · 203-374-9816Ilja Hulinsky · Principal investigatorMore trials in Bridgeport
- CMR of Greater New Haven, LLC · Hamden, CT 06517Jillian Reid · Principal investigatorMore trials in Hamden
FL
- Arrow Clinical Trials · Daytona Beach, FL 32117 · Study contact · 386-278-8000David Billmeier · Principal investigatorMore trials in Daytona Beach
- Care Access - Delray Beach · Delray Beach, FL 33484 · Study contact · 401-773-7855Sudhir Bansal · Principal investigatorMore trials in Delray Beach
- Fleming Island Center for Clinical Research · Fleming Island, FL 32003 · Study contact · 904-621-0390Jennifer Sidey · Principal investigatorMore trials in Fleming Island
- Nature Coast Clinical Research - Inverness · Inverness, FL 34452 · Study contact · 352-341-2100Paul Hellstern · Principal investigatorMore trials in Inverness
- Jacksonville Center for Clinical Research · Jacksonville, FL 32216 · Study contact · 904-730-0101Jeffry Jacqmein · Principal investigatorMore trials in Jacksonville
- Flourish Research Acquisition, LLC dba Flourish Research - North Miami · Miami, FL 33138 · Study contact · 786-772-0411Rimsky Denis · Principal investigatorMore trials in Miami
- New Horizon Research Center · Miami, FL 33165 · Study contact · 305-226-3933Lazaro Nunez · Principal investigatorMore trials in Miami
- Adult Medicine of Lake County, Inc. · Mt. Dora, FL 32757 · Study contact · 352-383-8222Shirley Nagel · Principal investigatorMore trials in Mt. Dora
- American Research Centers of Florida · Pembroke Pines, FL 33027 · Study contact · 954-237-3799Luis del Prado Rodriguez · Principal investigatorMore trials in Pembroke Pines
- Clinical Site Partners, LLC dba Flourish Research · Winter Park, FL 32789 · Study contact · 407-740-8078Monica Aggarwal · Principal investigatorMore trials in Winter Park
GA
- Teak Research Consults - Dunwoody · Dunwoody, GA 30338 · Study contact · 470-403-4755Aakar Thaker · Principal investigatorMore trials in Dunwoody
- Teak Research Consults · Lawrenceville, GA 30043Kamar Alabi · Principal investigatorMore trials in Lawrenceville
- The Jones Center Clinical Research · Macon, GA 31210Susan Garcia Castillo · Principal investigatorMore trials in Macon
HI
- Pacific Diabetes & Endocrine Center · Honolulu, HI 96817 · Study contact · 808-526-0303ALAN PARSA · Principal investigatorMore trials in Honolulu
IL
- NorthShore University Health System · Skokie, IL 60077 · Study contact · 847-663-8540Liana Billings · Principal investigatorMore trials in Skokie
IN
- DM Clinical Research - Indianapolis · Indianapolis, IN 46254 · Study contact · 463-271-3050Brandon Essink · Principal investigatorMore trials in Indianapolis
LA
- Clinical Trials Management, LLC d/b/a Flourish Research · Metairie, LA 70006 · Study contact · 504-455-1310David Dulitz · Principal investigatorMore trials in Metairie
- IMA Clinical Research Monroe - Armand · Monroe, LA 71201Clinton Guillory · Principal investigatorMore trials in Monroe
MA
- Lucida Clinical Trials · New Bedford, MA 02740 · Study contact · 508-720-2015David Shih · Principal investigatorMore trials in New Bedford
MD
- Centennial Medical Group · Columbia, MD 21045 · Study contact · 410-730-3399Rajiv Dua · Principal investigatorMore trials in Columbia
MO
- Clinical Research Professionals · Chesterfield, MO 63005 · Study contact · 636-220-1200Timothy Jennings · Principal investigatorMore trials in Chesterfield
- Clinvest Headlands Llc · Springfield, MO 65807 · Study contact · 417-883-7889Cory Bethmann · Principal investigatorMore trials in Springfield
NC
- PharmQuest Life Sciences, LLC · Greensboro, NC 27408 · Study contact · 336-574-8020Alexander Murray · Principal investigatorMore trials in Greensboro
- West Clinical Research · Morehead City, NC 28557 · Study contact · 252-515-0050Patrick Morgante · Principal investigatorMore trials in Morehead City
- Trial Management Associates - Wilmington - Floral Parkway · Wilmington, NC 28403William Jones · Principal investigatorMore trials in Wilmington
ND
- Lillestol Research · Fargo, ND 58104 · Study contact · 701-232-7705Michael Lillestol · Principal investigatorMore trials in Fargo
NJ
- Hypertension & Nephrology Association · Eatontown, NJ 07724spiros Arbes · Principal investigatorMore trials in Eatontown
- IMA Clinical Research Warren · Warren Township, NJ 07059Nancy Phillips · Principal investigatorMore trials in Warren Township
NM
- Albuquerque Clinical Trials, Inc. · Albuquerque, NM 87102 · Study contact · 505-224-7407Satkirin Khalsa · Principal investigatorMore trials in Albuquerque
NY
- NYC Research INC · Long Island City, NY 11106 · Study contact · 516-574-9232Anastasios Manessis · Principal investigatorMore trials in Long Island City
OH
- Care Access - Lima · Lima, OH 45805Jimmy Alele · Principal investigatorMore trials in Lima
OR
- Summit Headlands · Portland, OR 97210Andre Barkhuizen · Principal investigatorMore trials in Portland
PA
- Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair · Pittsburgh, PA 15243 · Study contact · 412-942-0023Daniel Austin · Principal investigatorMore trials in Pittsburgh
- Preferred Primary Care Physicians · Uniontown, PA 15401 · Study contact · 724-438-1479Richard Cook II · Principal investigatorMore trials in Uniontown
SC
- Accellacare - Mt Pleasant · Mt. Pleasant, SC 29464 · Study contact · 843-849-1880Richard Mills · Principal investigatorMore trials in Mt. Pleasant
TX
- IMA Clinical Research Austin · Austin, TX 78745Yu-Mei Liu · Principal investigatorMore trials in Austin
- Private Practice - Dr. Osvaldo A. Brusco · Corpus Christi, TX 78414 · Study contact · 361-885-0448Osvaldo Brusco · Principal investigatorMore trials in Corpus Christi
- Velocity Clinical Research, Dallas · Dallas, TX 75230Dan Lender · Principal investigatorMore trials in Dallas
- Diabetes and Thyroid Center of Ft. Worth · Fort Worth, TX 76132 · Study contact · 817-263-0007Anjanette Tan · Principal investigatorMore trials in Fort Worth
- Juno Research · Houston, TX 77040 · Study contact · 713-779-5494Damaris Vega · Principal investigatorMore trials in Houston
- Southern Endocrinology Associates · Mesquite, TX 75149 · Study contact · 214-693-0904Sumana Gangi · Principal investigatorMore trials in Mesquite
- Research Your Health · Plano, TX 75093 · Study contact · 9729991155 x103Michele Reynolds · Principal investigatorMore trials in Plano
- IMA Clinical Research San Antonio · San Antonio, TX 78229 · Study contact · 210-692-7157Priscilla Thomas · Principal investigatorMore trials in San Antonio
UT
- Ogden Clinic - Canyon View · Ogden, UT 84404 · Study contact · 385-271-0684Stephen Bruce · Principal investigatorMore trials in Ogden
- Diabetes & Endocrine Treatment Specialists · Sandy City, UT 84093 · Study contact · 801-816-1010Timothy Graham · Principal investigatorMore trials in Sandy City