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Augmented Depression Therapy (ADepT) Case Series

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 65 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at what patients think of Augmented Depression Therapy (ADepT) and how well it works. ADepT is talk therapy that helps build well-being and is given as usual care. The study is for adults ages 18 to 65 who currently have major depression.

This research study plans to examine the use of Augmented Depression Therapy (ADepT) in order to evaluate what patients think about ADepT and how well it works. ADepT is a type of therapy that builds wellbeing and is being provided to you as standard of care. ADepT treatment consists of 15 therapy sessions (typically provided weekly) with each session lasting around 60 minutes. Following these sessions, you can receive five optional booster sessions over the next 12 months with each of these lasting around 60 minutes. Ultimately, the timing and duration of these sessions will be determined between you and your provider and scheduled accordingly. As part of this study you will be randomized (randomly assigned) to different research assessment lengths before the start of treatment and then will complete assessments for the 12 months following the end of the weekly portion of ADepT treatment. The length of your participation will be between 70 weeks to 82 weeks.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 18 to 65 years old.
  • A study interview shows that you currently have an episode of major depression.
  • You score above 10 on the PHQ-9, a survey about depression symptoms.
  • You can read and speak English well enough to agree to join, use therapy materials, and complete study surveys without a translator.

Who can't join

  • You have bipolar disorder or a psychotic disorder, which can affect your sense of what is real.
  • You have a history of learning disabilities or brain changes caused by injury or a disease of the brain or nerves.
  • You have a current alcohol or drug use disorder, or your use would keep you from taking part in ADepT.
  • You have a serious risk of self-harm or thoughts of suicide that cannot be safely managed during ADepT.
  • You are receiving talk therapy from another provider. Switching providers or treatments may be discussed under clinic rules.
  • You are receiving transcranial magnetic stimulation (magnetic treatment for the brain), ketamine, esketamine, or electroconvulsive therapy (electrical treatment for the brain). A stable dose of an antidepressant is allowed.
  • You have another mental health condition judged to be your main condition.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Aged 18 -65 2. Currently experiencing a major depressive episode based on the Quick Structured Clinical Interview for DSM-5 Disorders (QuickSCID-5; First \& Williams, 2021) 3. Scoring \> 10 on the PHQ-9 4. Have sufficient knowledge of written and spoken English to provide consent and utilize therapy resources and take assessment measures throughout the protocol without the assistance of a translator. Exclusion Criteria: 1. Diagnosis of a psychotic or bipolar disorder 2. History of learning disabilities or organic brain change (e.g., from injury or from neurological disorders) 3. Active alcohol or substance use disorder or level of use that would interfere with ability to engage in ADepT treatment 4. Current marked risk to self (self-harm or suicidal ideation) that cannot be managed safely within the ADepT treatment frame 5. Patients cannot be enrolled while they are currently receiving psychotherapy from a different provider in line with current clinic policy and APA ethical guidelines. The possibility of switching providers/treatments will be addressed following established departmental policies and procedures, transcranial magnetic stimulation, ketamine, esketamine, or electroconvulsive therapy. Patients receiving a stable dose of an antidepressant agent will be considered eligible. 6. Presence of another psychiatric disorder judged to be primary

Study sites (1)

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