RecruitingPhase 1 / Phase 2NCT07020221
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Sponsor: Verastem, Inc.
Los Angeles, CA · +12 more sites
Colorectal Cancer clinical trials in Los Angeles, CA
55 recruiting colorectal cancer studies with a site in Los Angeles, CA.
All trials in Los Angeles, CA · All Colorectal Cancer trials
RecruitingPhase 1 / Phase 2NCT05786924
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Sponsor: Institut de Recherches Internationales Servier
Los Angeles, CA · San Francisco, CA · +18 more sites
RecruitingPhase 2NCT07023289
A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
Sponsor: AbbVie
Fullerton, CA · Los Angeles, CA · +20 more sites
RecruitingPhase 3NCT07775287
Study of Petosemtamab Plus Chemotherapy Versus Cetuximab or Bevacizumab Plus Chemotherapy in RAS and BRAF Wild Type, Recurrent, Unresectable or Metastatic Colorectal Cancer (LiGeR-CRC2)
Sponsor: Genmab
Los Angeles, CA · +2 more sites
RecruitingPhase 1 / Phase 2NCT05919264
FOG-001 in Locally Advanced or Metastatic Solid Tumors
Sponsor: Parabilis Medicines, Inc.
Los Angeles, CA · Palo Alto, CA · San Francisco, CA · +28 more sites
RecruitingPhase 1 / Phase 2NCT06710756
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Sponsor: Perspective Therapeutics
Los Angeles, CA · +14 more sites
RecruitingPhase 3NCT06997497
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Sponsor: Merck Sharp & Dohme LLC
Fountain Valley, CA · Los Angeles, CA · Sacramento, CA · +45 more sites
RecruitingPhase 1NCT04429542
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
Sponsor: Bicara Therapeutics
La Jolla, CA · Los Angeles, CA · +12 more sites
RecruitingPhase 1 / Phase 2NCT06428409
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Sponsor: Merck Sharp & Dohme LLC
Los Angeles, CA · +12 more sites
RecruitingPhase 3NCT07228832
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Sponsor: Summit Therapeutics
Beverly Hills, CA · Cerritos, CA · +109 more sites
RecruitingPhase 2NCT07446322
FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer
Sponsor: Oncolytics Biotech
Beverly Hills, CA · Encino, CA · Koreatown, CA · +14 more sites
RecruitingPhase 2NCT05673148
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial
Sponsor: Alliance for Clinical Trials in Oncology
Beverly Hills, CA · Irvine, CA · Los Angeles, CA · +185 more sites
RecruitingPhase 1NCT05877599
A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
Sponsor: AstraZeneca
Duarte, CA · Los Angeles, CA · Newport Beach, CA · +17 more sites
RecruitingPhase 1 / Phase 2NCT05482893
Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or Targeted Therapy and/or ICI, for the Treatment of Patients With Advanced Gastrointestinal Cancers, Including Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)
Sponsor: Phanes Therapeutics
Duarte, CA · Los Angeles, CA · +9 more sites
RecruitingPhase 1NCT06004245
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
Sponsor: Vividion Therapeutics, Inc.
Duarte, CA · Irvine, CA · Los Angeles, CA · +13 more sites
RecruitingPhase 1NCT06218914
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
Sponsor: AstraZeneca
Duarte, CA · Los Angeles, CA · Newport Beach, CA · +15 more sites
RecruitingPhase 1 / Phase 2NCT06047379
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Sponsor: Neonc Technologies, Inc.
Beverly Hills, CA · Glendale, CA · Los Angeles, CA · +5 more sites
RecruitingPhase 2NCT05489211
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Sponsor: AstraZeneca
Los Angeles, CA · San Diego, CA · Santa Rosa, CA · +15 more sites
RecruitingPhase 1 / Phase 2NCT06445062
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
Sponsor: Revolution Medicines, Inc.
La Jolla, CA · Los Angeles, CA · +29 more sites
RecruitingPhase 1 / Phase 2NCT07262619
EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
Sponsor: Eikon Therapeutics
Los Angeles, CA · +9 more sites
RecruitingPhase 1 / Phase 2NCT07488676
A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors
Sponsor: Astellas Pharma Global Development, Inc.
Los Angeles, CA · +17 more sites
RecruitingPhase 1NCT07217171
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas
Sponsor: EvolveImmune United, Inc
Duarte, CA · Los Angeles, CA · San Francisco, CA · +13 more sites
RecruitingPhase 1NCT06440005
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
Sponsor: Angiex, Inc.
Los Angeles, CA · +6 more sites
RecruitingNot applicableNCT05984589
Personalized Health Self-Management Training for Colorectal Cancer Survivors
Sponsor: University of Southern California
Los Angeles, CA
RecruitingPhase 3NCT06252649
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Sponsor: Amgen
Fullerton, CA · Long Beach, CA · Los Alamitos, CA · +23 more sites
RecruitingNot applicableNCT06568016
A Clinic-wide Intervention (Primary Care-GI Connect) for Improving Rates of Colonoscopy After Abnormal Fecal Immunochemical Test Result in Patients at Federally Qualified Health Centers
Sponsor: Jonsson Comprehensive Cancer Center
Los Angeles, CA
RecruitingPhase 1NCT07216105
FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors
Sponsor: Fate Therapeutics
La Jolla, CA · Los Angeles, CA · +3 more sites
RecruitingPhase 1NCT07321106
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer
Sponsor: Cartography Biosciences
Duarte, CA · Los Angeles, CA · +7 more sites
RecruitingPhase 1 / Phase 2NCT04851119
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Sponsor: Children's Oncology Group
Los Angeles, CA · Orange, CA · Palo Alto, CA · +18 more sites
RecruitingPhase 1NCT06225011
Fluoxetine for the Modification of Colorectal Tumor Immune Cells Before Surgery in Patients With Colorectal Cancer
Sponsor: Jonsson Comprehensive Cancer Center
Los Angeles, CA
RecruitingPhase 2NCT06792695
A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer
Sponsor: AstraZeneca
Los Angeles, CA · +13 more sites
RecruitingPhase 1 / Phase 2NCT04895709
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
Sponsor: Bristol-Myers Squibb
Clovis, CA · Los Angeles, CA · Newport Beach, CA · +8 more sites
RecruitingPhase 1NCT07066657
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
Sponsor: ArriVent BioPharma, Inc.
Los Angeles, CA · San Francisco, CA · +8 more sites
RecruitingPhase 1NCT06242470
A Study of MGC026 in Participants With Advanced Solid Tumors
Sponsor: MacroGenics
Los Angeles, CA · +6 more sites
RecruitingPhase 1 / Phase 2NCT06330064
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Sponsor: Daiichi Sankyo
Los Angeles, CA · Whittier, CA · +15 more sites
RecruitingPhase 1 / Phase 2NCT04657068
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Sponsor: Artios Pharma Ltd
Los Angeles, CA · Santa Barbara, CA · Santa Rosa, CA · +38 more sites
RecruitingPhase 1 / Phase 2NCT03526835
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Sponsor: Merus B.V.
La Jolla, CA · Los Angeles, CA · San Diego, CA · +28 more sites
RecruitingPhase 1NCT06562192
Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
Sponsor: Novartis Pharmaceuticals
Los Angeles, CA · Palo Alto, CA · +7 more sites
RecruitingPhase 2NCT06948448
A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer
Sponsor: Ono Pharmaceutical Co., Ltd.
Los Angeles, CA · +10 more sites
RecruitingPhase 2NCT06937177
Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing Chemotherapy
Sponsor: Endevica Bio
Los Angeles, CA · Santa Monica, CA · +23 more sites
RecruitingPhase 1NCT07337525
A First in Human Study of PLT012 in Participants With Solid Tumor Cancers
Sponsor: Pilatus Biosciences Inc
Los Angeles, CA · +3 more sites
RecruitingPhase 1 / Phase 2NCT07169734
A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
Sponsor: Alentis Therapeutics AG
Los Angeles, CA · +8 more sites
RecruitingPhase 1NCT04678648
A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
Sponsor: RasCal Therapeutics, Inc.
Los Angeles, CA · +2 more sites
RecruitingPhase 1 / Phase 2NCT06051695
A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
Sponsor: A2 Biotherapeutics Inc.
La Jolla, CA · Los Angeles, CA · Stanford, CA · +9 more sites
RecruitingPhase 1 / Phase 2NCT03947385
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
Sponsor: IDEAYA Biosciences
Los Angeles, CA · San Francisco, CA · +10 more sites
RecruitingPhase 1NCT06917079
BBO-11818 in Adult Subjects With KRAS Mutant Cancer
Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
Los Angeles, CA · Sacramento, CA · San Diego, CA · +13 more sites
RecruitingNot applicableNCT05297734
Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer
Sponsor: Stanford University
Duarte, CA · Fresno, CA · Fruitdale, CA · +14 more sites
RecruitingPhase 2NCT07033026
An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.
Sponsor: NGM Biopharmaceuticals, Inc
Los Angeles, CA · Santa Rosa, CA · +10 more sites
RecruitingPhase 1NCT06336902
Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer
Sponsor: University of Southern California
Fullerton, CA · Los Angeles, CA
RecruitingNot applicableNCT04907643
Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
Sponsor: Cedars-Sinai Medical Center
Los Angeles, CA
Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.