Phase 2 Depression clinical trials

45 recruiting Phase 2 depression studies in the US. What trial phases mean

Other phases

RecruitingPhase 2NCT07219875

Training Reward Responsiveness Through Virtual Reality

Sponsor: University of California, Los Angeles

Los Angeles, CA

RecruitingPhase 2NCT06188923

A New Intervention to Improve Function in Veterans With Anxiety and Depression

Sponsor: VA Office of Research and Development

Durham, NC

RecruitingPhase 2NCT07610473

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

Sponsor: Draig Therapeutics Ltd

Phoenix, AZ · Little Rock, AR · Bellflower, CA · +20 more sites

RecruitingPhase 2NCT06656416

ALTO-100 in Bipolar Disorder With Depression (BD-D)

Sponsor: Alto Neuroscience

Birmingham, AL · Chandler, AZ · Phoenix, AZ · +55 more sites

RecruitingPhase 2NCT07300969

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

Sponsor: Draig Therapeutics Ltd

Bentonville, AR · Little Rock, AR · Oceanside, CA · +20 more sites

RecruitingPhase 2NCT07284667

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

Sponsor: ACADIA Pharmaceuticals Inc.

Birmingham, AL · Chino, CA · Glendale, CA · +25 more sites

RecruitingPhase 2NCT07003997

JAK Signaling in Depression

Sponsor: Emory University

Atlanta, GA

RecruitingPhase 2NCT07610369

The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

Sponsor: Yale University

New Haven, CT

RecruitingPhase 2NCT07608796

JAK Signaling in Depression and Cognition in Male Football Players

Sponsor: Emory University

Atlanta, GA

RecruitingPhase 2NCT07002034

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

Sponsor: Reunion Neuroscience Inc

Birmingham, AL · Tucson, AZ · San Diego, CA · +29 more sites

RecruitingPhase 2NCT06200155

Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

Sponsor: M.D. Anderson Cancer Center

Houston, TX

RecruitingPhase 2NCT06580145

Leucine in Midlife Depression

Sponsor: Emory University

Atlanta, GA

RecruitingPhase 2NCT07639359

Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients

Sponsor: Hospital Italiano de Buenos Aires

Jacksonville, FL

RecruitingPhase 2NCT05895747

5-HTP and Creatine for Depression R33 Phase

Sponsor: University of Utah

Salt Lake City, UT

RecruitingPhase 2NCT06867549

Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II

Sponsor: Washington University School of Medicine

St Louis, MO

RecruitingPhase 2NCT06696755

A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder

Sponsor: AbbVie

Huntsville, AL · Chandler, AZ · Tucson, AZ · +30 more sites

RecruitingPhase 2NCT06512194

Investigation to Understand and Optimize Psilocybin

Sponsor: Charles Raison

Edwards, CO

RecruitingPhase 2NCT06455293

Psilocybin Therapy for Depression in Parkinson's Disease

Sponsor: Joshua Woolley, MD, PhD

San Francisco, CA

RecruitingPhase 2NCT06820723

A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety

Sponsor: Ohio State University

Columbus, OH

RecruitingPhase 2NCT06591091

Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression

Sponsor: University of Illinois at Chicago

Chicago, IL

RecruitingPhase 2NCT06290063

Cannabidiol and Older Adult Cannabis Users

Sponsor: University of Colorado, Boulder

Boulder, CO

RecruitingPhase 2NCT06524830

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

Sponsor: atai Therapeutics, Inc.

Tucson, AZ · Little Rock, AR · +31 more sites

RecruitingPhase 2NCT06345859

Regulation of Affect and Physiology in Depression

Sponsor: University of Southern California

Los Angeles, CA

RecruitingPhase 2NCT02122562

Ketamine Alcohol (in Treatment-Resistant Depression)

Sponsor: Mark Niciu

Iowa City, IA

RecruitingPhase 2NCT07493317

Neutralizing Interleukin (IL)-6

Sponsor: Icahn School of Medicine at Mount Sinai

New York, NY

RecruitingPhase 2NCT07553637

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

Sponsor: Alto Neuroscience

Birmingham, AL · Dothan, AL · Phoenix, AZ · +35 more sites

RecruitingPhase 2NCT06263660

Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression

Sponsor: Laureate Institute for Brain Research, Inc.

Tulsa, OK

RecruitingPhase 2NCT06402955

Imaging Depression in Parkinson's Disease

Sponsor: Yale University

New Haven, CT

RecruitingPhase 2NCT06073886

Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

Sponsor: University of California, Los Angeles

Westwood, Los Angeles, CA

RecruitingPhase 2NCT06375083

Computerized Cognitive Behavioral Therapies for Suicide Prevention and Depression

Sponsor: VA Eastern Colorado Health Care System

Aurora, CO

RecruitingPhase 2NCT06839859

Family Acceptance Project Online (Pilot RCT)

Sponsor: University of Michigan

Ann Arbor, MI

RecruitingPhase 2NCT06419439

Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression

Sponsor: VA Office of Research and Development

Ann Arbor, MI

RecruitingPhase 2NCT06854224

Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial

Sponsor: Marianne Goodman

The Bronx, NY

RecruitingPhase 2NCT05570812

Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

Sponsor: Massachusetts General Hospital

Boston, MA

RecruitingPhase 2NCT06266611

Cannabis for Palliative Care in Cancer

Sponsor: University of Colorado, Boulder

Aurora, CO

RecruitingPhase 2NCT06559826

Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression

Sponsor: Icahn School of Medicine at Mount Sinai

New York, NY

RecruitingPhase 2NCT06136546

Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

Sponsor: Massachusetts General Hospital

Boston, MA

RecruitingPhase 2NCT06858189

Promoting Active Therapy: Path to Wellness

Sponsor: Kansas State University

Manhattan, KS

Not yet recruitingPhase 2NCT07810738

The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.

Sponsor: Washington University School of Medicine

St Louis, MO · Pittsburgh, PA

Not yet recruitingPhase 2NCT07868718

Peer Support for Family Caregivers of Older Adults Living With Dementia

Sponsor: Ohio State University

Columbus, OH

Not yet recruitingPhase 2NCT07772531

A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder

Sponsor: Bristol-Myers Squibb

Phoenix, AZ · Little Rock, AR · Rogers, AR · +18 more sites

Not yet recruitingPhase 2NCT07734701

Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder

Sponsor: Sherwood Brown, MD, PhD

Dallas, TX · Richardson, TX

Not yet recruitingPhase 2NCT07479550

Study of Psilocybin Under Anesthesia Controlled by EEG

Sponsor: Stanford University

Stanford, CA

Not yet recruitingPhase 2NCT06710431

A Study of the Safety and Exploratory Efficacy of Oral AFA-281 in Patients with Alcohol Use Disorder

Sponsor: Afasci Inc

Los Angeles, CA

Not yet recruitingPhase 2NCT06228391

Ketamine Treatment for PTSD and MDD in TBI

Sponsor: Minneapolis Veterans Affairs Medical Center

Minneapolis, MN

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.