Phase 1 Lung Cancer clinical trials

85 recruiting Phase 1 lung cancer studies in the US. What trial phases mean

Other phases

RecruitingPhase 1NCT07509034

Autologous B7-H3 Chimeric Antigen Receptor T Cells in Previously Treated Extensive-Stage Small Cell Lung Cancer With Recurrent or Refractory Disease

Sponsor: National Cancer Institute (NCI)

Bethesda, MD

RecruitingPhase 1NCT06066138

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

Sponsor: National Cancer Institute (NCI)

Bethesda, MD

RecruitingPhase 1NCT06179069

A Study of ZL-1310 in Subjects With Small Cell Lung Cancer

Sponsor: Zai Lab (Shanghai) Co., Ltd.

Duarte, CA · New Haven, CT · Sarasota, FL · +8 more sites

RecruitingPhase 1NCT06465069

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

Sponsor: Eli Lilly and Company

Duarte, CA · La Jolla, CA · Los Angeles, CA · +20 more sites

RecruitingPhase 1NCT06885697

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

Sponsor: National Cancer Institute (NCI)

Bethesda, MD

RecruitingPhase 1NCT03460977

A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma

Sponsor: Pfizer

Tucson, AZ · +42 more sites

RecruitingPhase 1NCT06545331

Study of XB010 in Subjects With Solid Tumors

Sponsor: Exelixis

Irvine, CA · Los Angeles, CA · Washington D.C., DC · +13 more sites

RecruitingPhase 1NCT07462377

A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

Sponsor: EpiBiologics

Los Angeles, CA · East Brunswick, NJ · Lake Success, NY · +3 more sites

RecruitingPhase 1NCT07094204

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

Sponsor: Astellas Pharma Inc

Santa Monica, CA · Atlanta, GA · Jefferson, LA · +8 more sites

RecruitingPhase 1NCT07519655

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

Sponsor: Pfizer

Denver, CO · New Haven, CT · +8 more sites

RecruitingPhase 1NCT07261631

Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors

Sponsor: Novartis Pharmaceuticals

Princeton, NJ

RecruitingPhase 1NCT07164313

A Study of ZW251 in Participants With Advanced Solid Tumors

Sponsor: Zymeworks BC Inc.

San Francisco, CA · Santa Monica, CA · Louisville, KY · +5 more sites

RecruitingPhase 1NCT07454642

AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors

Sponsor: Avacta Life Sciences Ltd

Scottsdale, AZ · Sarasota, FL · Chicago, IL · +4 more sites

RecruitingPhase 1NCT06270706

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

Sponsor: Pliant Therapeutics, Inc.

New Haven, CT · Atlanta, GA · Grand Rapids, MI · +13 more sites

RecruitingPhase 1NCT07814248

A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Select Advanced Solid Tumors

Sponsor: TwoStep Therapeutics, Inc.

Maumee, OH · Portland, OR · Fairfax, VA

RecruitingPhase 1NCT05877599

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

Sponsor: AstraZeneca

Gilbert, AZ · Duarte, CA · Los Angeles, CA · +17 more sites

RecruitingPhase 1NCT07140315

DK222 Study at Hopkins

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, MD

RecruitingPhase 1NCT07578571

A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

Sponsor: Immunome, Inc.

New Haven, CT · Sarasota, FL · Boston, MA · +1 more sites

RecruitingPhase 1NCT07705035

DBC-664 in Adult Patients With Solid Tumors

Sponsor: Duboce Biopharmaceuticals, Inc.

Denver, CO · Grand Rapids, MI · East Brunswick, NJ · +3 more sites

RecruitingPhase 1NCT07277413

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

Sponsor: IDEAYA Biosciences

Goodyear, AZ · Phoenix, AZ · Duarte, CA · +20 more sites

RecruitingPhase 1NCT06218914

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

Sponsor: AstraZeneca

Duarte, CA · Los Angeles, CA · Newport Beach, CA · +15 more sites

RecruitingPhase 1NCT07037758

A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)

Sponsor: Amgen

Gilbert, AZ · Los Angeles, CA · Tampa, FL · +10 more sites

RecruitingPhase 1NCT07229313

A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors

Sponsor: Kivu Bioscience Inc.

Santa Monica, CA · New Have, CT

RecruitingPhase 1NCT06858813

A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC)

Sponsor: AbbVie

Duarte, CA · Irvine, CA · Los Angeles, CA · +7 more sites

RecruitingPhase 1NCT07006727

Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

Sponsor: Novartis Pharmaceuticals

Iowa City, IA · Boston, MA · Royal Oak, MI · +1 more sites

RecruitingPhase 1NCT05983432

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

Sponsor: SystImmune Inc.

Beverly Hills, CA · Duarte, CA · Orange, CA · +19 more sites

RecruitingPhase 1NCT06529822

Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease

Sponsor: Washington University School of Medicine

Orlando, FL · St Louis, MO · Columbus, OH

RecruitingPhase 1NCT07617337

AQUA07 in Patients With ALK-Positive Non-Small Cell Lung Cancer

Sponsor: Chugai Pharmaceutical

Houston, TX

RecruitingPhase 1NCT07020117

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

Sponsor: Aktis Oncology, Inc.

Duarte, CA · Irvine, CA · Miami, FL · +11 more sites

RecruitingPhase 1NCT07080242

Evaluating BL-M14D1 in Subjects With Locally Advanced or Metastatic Small Cell Lung Cancer and Neuroendocrine Tumors

Sponsor: SystImmune Inc.

Huntsville, AL · Glendale, CA · Long Beach, CA · +21 more sites

RecruitingPhase 1NCT07217171

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

Sponsor: EvolveImmune United, Inc

Duarte, CA · Los Angeles, CA · San Francisco, CA · +13 more sites

RecruitingPhase 1NCT05245500

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Sponsor: Bristol-Myers Squibb

Phoenix, AZ · Lone Tree, CO · Jacksonville, FL · +22 more sites

RecruitingPhase 1NCT06458712

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

Sponsor: Duke Street Bio Ltd

Sacramento, CA · New Haven, CT · New York, NY · +1 more sites

RecruitingPhase 1NCT07027514

A Study of Tolododekin Alfa (ANK-101) in Combination With an Anti-PD-1/PD-L1 Antibody in Participants With Advanced Non-Small Cell Lung Cancer

Sponsor: Ankyra Therapeutics, Inc

Coral Gables, FL · Jacksonville, FL · Peoria, IL · +8 more sites

RecruitingPhase 1NCT07216105

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

Sponsor: Fate Therapeutics

La Jolla, CA · Los Angeles, CA · Minneapolis, MN · +2 more sites

RecruitingPhase 1NCT06582017

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

Sponsor: Nammi Therapeutics Inc

Los Angeles, CA · +7 more sites

RecruitingPhase 1NCT07660055

Study of [177Lu]Lu-DWJ155 and [68Ga]Ga-DWJ155 in Patients With Solid Tumors

Sponsor: Novartis Pharmaceuticals

Omaha, NE

RecruitingPhase 1NCT07784959

Study of NXP900 With Lorlatinib in ALK+ Lung Cancer

Sponsor: Nuvectis Pharma, Inc.

Fairfax, VA

RecruitingPhase 1NCT06586515

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

Sponsor: Eli Lilly and Company

Duarte, CA · Santa Monica, CA · Denver, CO · +22 more sites

RecruitingPhase 1NCT06922539

Phase 1 Trial of ST-001 nanoFenretinide in Relapsed/ Refractory Small Cell Lung Cancer

Sponsor: SciTech Development, Inc.

Los Angeles, CA · Detroit, MI

RecruitingPhase 1NCT07241039

A Study to Assess the Adverse Events, Change in Disease Activity, and How Oral ABBV-711 Tablets Move Through the Body as a Monotherapy and in Combination With Intravenously Infused Budigalimab (ABBV-181), in Adults With Advanced Squamous Tumors

Sponsor: AbbVie

Duarte, CA · Irvine, CA · Chicago, IL · +3 more sites

RecruitingPhase 1NCT07619599

A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving Pembrolizumab

Sponsor: City of Hope Medical Center

Duarte, CA

RecruitingPhase 1NCT06242470

A Study of MGC026 in Participants With Advanced Solid Tumors

Sponsor: MacroGenics

Los Angeles, CA · Grand Rapids, MI · Lake Success, NY · +4 more sites

RecruitingPhase 1NCT06807632

A Study of Valemetostat in Combination With Atezolizumab in People With Lung Cancer

Sponsor: Memorial Sloan Kettering Cancer Center

Basking Ridge, NJ · Middletown, NJ · Montvale, NJ · +4 more sites

RecruitingPhase 1NCT05401110

Study of Osimertinib With Carotuximab in Advanced, EGFR-mutated Non-Small Cell Lung Cancer

Sponsor: Karen Reckamp, MD, MS

Beverly Hills, CA · Los Angeles, CA · +2 more sites

RecruitingPhase 1NCT06910657

IDOV-Immune for Advanced Solid Tumors

Sponsor: ViroMissile, Inc.

St Louis, MO · Houston, TX · San Antonio, TX

RecruitingPhase 1NCT07192900

Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease

Sponsor: David Bartlett, MD

Pittsburgh, PA

RecruitingPhase 1NCT07545954

DSP-0390 in Combination With Atezolizumab for Small Cell Lung Cancer

Sponsor: Washington University School of Medicine

St Louis, MO

RecruitingPhase 1NCT05433142

Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma

Sponsor: Xencor, Inc.

Phoenix, AZ · Duarte, CA · Sacramento, CA · +17 more sites

RecruitingPhase 1NCT06562192

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

Sponsor: Novartis Pharmaceuticals

Birmingham, AL · Los Angeles, CA · Palo Alto, CA · +6 more sites

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.