A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
A Randomized, Open-label, Parallel-group Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Elecoglipron Compared With Oral Semaglutide in Adults With Type 2 Diabetes Mellitus (Eluminate-2)
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increased cardiovascular risk that is inadequately managed alone or on stable treatment with other background glucose-lowering medication(s).
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Official eligibility criteria
Inclusion Criteria: * Diagnosed with Type 2 Diabetes Mellitus (T2DM) for at least 90 days prior to screening * T2DM inadequately managed with lifestyle management alone or on stable treatment with other background glucose-lowering medication(s) * HbA1c value of ≥ 7% to ≤ 10.5% (53 to 91.3 mmol/mol) * Increased risk of cardiovascular (CV) events defined by ≥1 of: documented coronary heart disease, peripheral arterial disease, ischemic cerebrovascular disease, or heart failure (NYHA II-III); or ≥2 CV risk factors * Body mass index (BMI) of ≥ 23 kg/m2 at screening * Stable body weight (self-reported or documented) for 90 days prior to screening Exclusion Criteria: * Type 1 Diabetes Mellitus (T1DM), secondary forms of diabetes (including congenital forms), or history of ketoacidosis or hyperosmolar coma * Currently receiving or anticipated to receive, therapeutic intervention for diabetic retinopathy and/or macular edema * Have had more than one episode of severe hypoglycemia within 180 days prior to screening or has a history of hypoglycemia unawareness or poor recognition of hypoglycemic symptoms * Clinically significant condition affecting the upper Gastrointestinal (GI) tract or chronic use of any medication that affects gastric motility or gastric emptying * History of acute or chronic pancreatitis * Severe congestive heart failure (NYHA IV) * History/family history of medullary thyroid cancer or multiple endocrine neoplasia type 2
Study sites (64)
AL
- Research Site · Birmingham, AL 35205More trials in Birmingham
AZ
- Research Site · Mesa, AZ 85213More trials in Mesa
- Research Site · Phoenix, AZ 85016More trials in Phoenix
- Research Site · Tempe, AZ 85281More trials in Tempe
CA
- Research Site · Covina, CA 91723More trials in Covina
- Research Site · Encinitas, CA 92024More trials in Encinitas
- Research Site · Garden Grove, CA 92844More trials in Garden Grove
- Research Site · Loma Linda, CA 92354More trials in Loma Linda
- Research Site · Long Beach, CA 90807More trials in Long Beach
- Research Site · Pomona, CA 91768More trials in Pomona
- Research Site · Sacramento, CA 95821More trials in Sacramento
CT
- Research Site · Bridgeport, CT 06606More trials in Bridgeport
FL
- Research Site · Crystal River, FL 34429More trials in Crystal River
- Research Site · Hollywood, FL 33021More trials in Hollywood
- Research Site · Jacksonville, FL 32209More trials in Jacksonville
- Research Site · Lake City, FL 32055More trials in Lake City
- Research Site · Leesburg, FL 34748More trials in Leesburg
- Research Site · Orlando, FL 32806More trials in Orlando
GA
- Research Site · Lilburn, GA 30047More trials in Lilburn
IA
- Research Site · Ames, IA 50010More trials in Ames
ID
- Research Site · Idaho Falls, ID 83404More trials in Idaho Falls
IL
- Research Site · Melrose Park, IL 60160More trials in Melrose Park
IN
- Research Site · Evansville, IN 47710More trials in Evansville
KS
- Research Site · Wichita, KS 67226More trials in Wichita
KY
- Research Site · Bowling Green, KY 42101More trials in Bowling Green
MD
- Research Site · Rockville, MD 20852More trials in Rockville
MI
- Research Site · Southfield, MI 48076More trials in Southfield
MN
- Research Site · Minneapolis, MN 55416More trials in Minneapolis
MO
- Research Site · Jefferson City, MO 65109More trials in Jefferson City
- Research Site · Kansas City, MO 64114More trials in Kansas City
NC
- Research Site · Durham, NC 27701More trials in Durham
- Research Site · Morehead City, NC 28557More trials in Morehead City
- Research Site · Raleigh, NC 27612More trials in Raleigh
- Research Site · Statesville, NC 28625More trials in Statesville
- Research Site · Wilmington, NC 28403More trials in Wilmington
NE
- Research Site · Omaha, NE 68114More trials in Omaha
NM
- Research Site · Albuquerque, NM 87112More trials in Albuquerque
NV
- Research Site · Henderson, NV 89052More trials in Henderson
- Research Site · Las Vegas, NV 89128More trials in Las Vegas
OH
- Research Site · Columbus, OH 43215More trials in Columbus
OK
- Research Site · Oklahoma City, OK 73134More trials in Oklahoma City
PA
- Research Site · Feasterville-Trevose, PA 19053More trials in Feasterville-Trevose
- Research Site · Philadelphia, PA 19114More trials in Philadelphia
SC
- Research Site · Myrtle Beach, SC 29572More trials in Myrtle Beach
- Research Site · North Charleston, SC 29405More trials in North Charleston
TN
- Research Site · Memphis, TN 38119More trials in Memphis
- Research Site · Morristown, TN 37813More trials in Morristown
TX
- Research Site · Dallas, TX 75390More trials in Dallas
- Research Site · Houston, TX 77004More trials in Houston
- Research Site · Houston, TX 77040More trials in Houston
- Research Site · Houston, TX 77079More trials in Houston
- Research Site · Katy, TX 77450More trials in Katy
- Research Site · San Antonio, TX 78229More trials in San Antonio
- Research Site · San Antonio, TX 78231More trials in San Antonio
- Research Site · Sugar Land, TX 77478More trials in Sugar Land
- Research Site · Weslaco, TX 78596More trials in Weslaco
UT
- Research Site · Bountiful, UT 84010More trials in Bountiful
- Research Site · Salt Lake City, UT 84124More trials in Salt Lake City
VA
- Research Site · Leesburg, VA 20176More trials in Leesburg
- Research Site · Norfolk, VA 23502More trials in Norfolk
WA
- Research Site · Renton, WA 98057More trials in Renton
- Research Site · Seattle, WA 98104More trials in Seattle
- Research Site · Seattle, WA 98105More trials in Seattle
WV
- Research Site · Morgantown, WV 26505More trials in Morgantown