A Study of EloraTZP in Adult Participants With Obesity Without Type 2 Diabetes
A Phase 3 Study to Investigate the Efficacy and Safety of LY900043 in Adult Participants With Obesity Without Type 2 Diabetes
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study tests how well EloraTZP, a mix of eloralintide and tirzepatide, helps adults with obesity lose weight and how safe it is. It compares EloraTZP with each drug alone and a placebo (a treatment with no active drug). The study is for adults without diabetes and lasts about 2 years.
The purpose of this study is to investigate the efficacy and safety of eloralintide and tirzepatide coformulation (EloraTZP) compared with tirzepatide, eloralintide and placebo for body weight reduction in participants with obesity. Participation in the study will last about 2 years.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Your weight has changed by less than 5% in the 90 days before screening, based on your report.
- You have a BMI of 35 or higher at screening. BMI is a measure based on height and weight.
- You report trying at least one diet to lose weight without success.
Who can't join
- You have had or plan to have surgery for obesity. Liposuction, fat freezing, or a tummy tuck is allowed if done more than 1 year before screening.
- You have had or plan to have a procedure using a scope or a device to treat obesity or type 2 diabetes. Past device treatment is allowed if the device was removed more than 6 months before screening.
- You have any type of diabetes.
- In the 90 days before screening, you had a heart attack, stroke, a procedure to restore blood flow to the heart, unstable angina (new or worsening heart-related chest pain), or a hospital stay for heart failure.
- You have or have had Class IV heart failure, the most severe level, which can cause symptoms even at rest.
- You took medicine to lower blood sugar in the 90 days before screening.
- You took medicine or other remedies meant for weight loss in the 90 days before screening.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * Have a stable self-reported body weight (\<5% body weight change) for 90 days prior to screening * Have a BMI of ≥35 kg/m2 at screening * Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity and/or type 2 diabetes (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes, type 2 diabetes, or any other type of diabetes * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure * Have taken any glucose-lowering medication within 90 days of screening * Have taken medications or alternative remedies intended for weight loss within 90 days of screening
Study sites (55)
AZ
- Care Access - 801 South Power Road, Mesa · Mesa, AZ 85206 · Study contact · 877-791-0656Michael Waters · Principal investigatorMore trials in Mesa
- Headlands Research - Scottsdale · Scottsdale, AZ 85260 · Study contact · 480-725-8708Benjamin Clark · Principal investigatorMore trials in Scottsdale
- Tucson Clinical Research Institute · Tucson, AZ 85712Girish Karamchandani · Principal investigatorMore trials in Tucson
CA
- Valley Clinical Trials, Inc. · Covina, CA 91723 · Study contact · 310-309-9491Linda Glaser · Principal investigatorMore trials in Covina
- Los Angeles Institute for Metabolic Research · Los Angeles, CA 90015 · Study contact · 213-373-8380Juan Frias · Principal investigatorMore trials in Los Angeles
- Peninsula Research Associates · Rolling Hills Estates, CA 90274 · Study contact · 3102651623Lawrence Sher · Principal investigatorMore trials in Rolling Hills Estates
- Artemis Institute for Clinical Research · San Diego, CA 92123 · Study contact · 858-278-3647Stacey Layle · Principal investigatorMore trials in San Diego
- Southern California Clinical Research · Santa Ana, CA 92701 · Study contact · 7144742173Wayne Ho · Principal investigatorMore trials in Santa Ana
CT
- Yale University School of Medicine · New Haven, CT 06519 · Study contact · (203) 785-7421Ania Jastreboff · Principal investigatorMore trials in New Haven
FL
- JEM Research Institute · Atlantis, FL 33462 · Study contact · 5619682933David Halpert · Principal investigatorMore trials in Atlantis
- K2 Medical Research - Maitland · Maitland, FL 32751 · Study contact · 407-810-2790Neel Patel · Principal investigatorMore trials in Maitland
- Flourish Research - Miami, LLC · Miami, FL 33135 · Study contact · 305-631-6704Mark Rosenthal · Principal investigatorMore trials in Miami
- Care Access - Tamarac · Tamarac, FL 33321 · Study contact · 877-791-0656Brad Lipson · Principal investigatorMore trials in Tamarac
- Care Access - Tampa · Tampa, FL 33625 · Study contact · 813-771-5980Shital Mehta · Principal investigatorMore trials in Tampa
GA
- Care Access - Dalton Walmart · Dalton, GA 30720 · Study contact · 877-791-0656Chukwukanene Ofiaeli · Principal investigatorMore trials in Dalton
- Teak Research Consults - Dunwoody · Dunwoody, GA 30338 · Study contact · 4704034755Aakar Thaker · Principal investigatorMore trials in Dunwoody
- Clinical Research Atlanta · Stockbridge, GA 30281 · Study contact · 770-507-6867Jason Agran · Principal investigatorMore trials in Stockbridge
- Rophe Adult and Pediatric Medicine/SKYCRNG · Union City, GA 30291 · Study contact · 470-317-3604Dwight Blake · Principal investigatorMore trials in Union City
HI
- East-West Medical Research Institute · Honolulu, HI 96814 · Study contact · 8085316886Cindy Pau · Principal investigatorMore trials in Honolulu
IL
- IMA Clinical Research Chicago · Chicago, IL 60641Nadijda Bassil · Principal investigatorMore trials in Chicago
IN
- DM Clinical Research - Indianapolis · Indianapolis, IN 46254 · Study contact · 463-271-3050Brandon Essink · Principal investigatorMore trials in Indianapolis
LA
- Care Access - Eunice · Eunice, LA 70535 · Study contact · 3374578841Randall Miller · Principal investigatorMore trials in Eunice
- Clinical Trials Management, LLC d/b/a Flourish Research · Metairie, LA 70006 · Study contact · 5044551310David Dulitz · Principal investigatorMore trials in Metairie
MA
- Brigham and Women's Hospital Diabetes Program · Boston, MA 02115 · Study contact · 6177324245Vanita Aroda · Principal investigatorMore trials in Boston
MD
- Pharmasite Research, Inc. · Baltimore, MD 21208 · Study contact · 410 602-1440Sarah Herts · Principal investigatorMore trials in Baltimore
- Care Access - Baltimore · Baltimore, MD 21213 · Study contact · 877-791-0656Peta-Gay Jackson Booth · Principal investigatorMore trials in Baltimore
MS
- SKY Integrative Medical Center/SKYCRNG · Ridgeland, MS 39157 · Study contact · 601-567-1321Bob Hutchins · Principal investigatorMore trials in Ridgeland
NC
- University of North Carolina Medical Center · Chapel Hill, NC 27514 · Study contact · 9849743004Klara Klein · Principal investigatorMore trials in Chapel Hill
- Medication Management · Greensboro, NC 27401 · Study contact · 3367636968James Franklin · Principal investigatorMore trials in Greensboro
- Care Access - Raleigh · Raleigh, NC 27607 · Study contact · 877-791-0656Chandar Abboy · Principal investigatorMore trials in Raleigh
NM
- IMA Clinical Research Albuquerque · Albuquerque, NM 87109 · Study contact · 5058483773Shenif Ladak · Principal investigatorMore trials in Albuquerque
NV
- IMA Clinical Research Las Vegas · Las Vegas, NV 89102 · Study contact · 702-463-8888Nasim Amjadi · Principal investigatorMore trials in Las Vegas
- Palm Research Center Sunset · Las Vegas, NV 89148Ellen Neylon · Principal investigatorMore trials in Las Vegas
NY
- NYC Research INC · Long Island City, NY 11106 · Study contact · 516-574-9232Anastasios Manessis · Principal investigatorMore trials in Long Island City
- Weill Cornell Medical College · New York, NY 10021 · Study contact · 646-962-2424Alpana Shukla · Principal investigatorMore trials in New York
- IMA Clinical Research NYC Midtown · New York, NY 10036Eli Shalenberg · Principal investigatorMore trials in New York
PA
- Clinical Research of Philadelphia · Philadelphia, PA 19114 · Study contact · 215-676-6696JOSEPH HEETHER · Principal investigatorMore trials in Philadelphia
- Keystone Clinical Studies · Plymouth Meeting, PA 19462Cameron Olezene · Principal investigatorMore trials in Plymouth Meeting
TN
- Clinical Neuroscience Solutions Inc. · Memphis, TN 38119 · Study contact · 9018431045Lisa Usdan · Principal investigatorMore trials in Memphis
TX
- JCCT - Juno Bellaire Site · Bellaire, TX 77401 · Study contact · 713-779-5494Rocio Harbison · Principal investigatorMore trials in Bellaire
- The University of Texas Health Science Center at Houston · Bellaire, TX 77401 · Study contact · 713-486-1350Deborah Horn · Principal investigatorMore trials in Bellaire
- Cedar Health Research · Dallas, TX 75251 · Study contact · 214-253-8170Sefanit Gebretsadik · Principal investigatorMore trials in Dallas
- Cedar Health Research - Euless · Euless, TX 76040 · Study contact · 2142538170Debbie Bridges · Principal investigatorMore trials in Euless
- Biopharma Informatic, LLC · Houston, TX 77043 · Study contact · 281-944-3610Agadadash Kuliev · Principal investigatorMore trials in Houston
- PlanIt Research, LLC · Houston, TX 77079 · Study contact · 713-973-3415Christina Michaelis · Principal investigatorMore trials in Houston
- Care Access - Houston - Clinical Trials Center by Walmart & Care Access · Houston, TX 77082 · Study contact · 877-791-0656Ali Bajwa · Principal investigatorMore trials in Houston
- Activian Clinical Research · Kingwood, TX 77339 · Study contact · 832 969 3401Martin Basaldua · Principal investigatorMore trials in Kingwood
- Clinical Trials of Texas, LLC · San Antonio, TX 78229 · Study contact · 210-949-0122Douglas Denham · Principal investigatorMore trials in San Antonio
- Consano Clinical Research, LLC · Shavano Park, TX 78231 · Study contact · 210-545-4900Michelle Welch · Principal investigatorMore trials in Shavano Park
- Care Access - Tyler - Clinical Trials Center by Walmart & Care Access · Tyler, TX 75704 · Study contact · 877-791-0656Alphonse Ekole · Principal investigatorMore trials in Tyler
UT
- Kalo Clinical Research · West Valley City, UT 84120Joshua Alam · Principal investigatorMore trials in West Valley City
VA
- Care Access - Arlington 2 · Arlington, VA 22206 · Study contact · 877-791-0656Chih Chao Yang · Principal investigatorMore trials in Arlington
- Washington Center for Weight Management and Research · Arlington, VA 22206 · Study contact · 7038070037Domenica Rubino · Principal investigatorMore trials in Arlington
- Health Research of Hampton Roads, Inc. · Newport News, VA 23606 · Study contact · 757-591-8100George Freeman · Principal investigatorMore trials in Newport News
- Eastern Virginia Medical School (EVMS) Medical Group · Norfolk, VA 23510 · Study contact · 757-446-5291Elias Siraj · Principal investigatorMore trials in Norfolk