Clinical trials in Irvine, CA

109 recruiting studies have a site in or near Irvine, CA, California.

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Showing 40 of 109 studies

RecruitingPhase 3NCT06136650

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

Sponsor: Merck Sharp & Dohme LLC

Irvine, CA · Los Angeles, CA · Orange, CA · +60 more sites

RecruitingPhase 3NCT03150693

Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

Sponsor: Alliance for Clinical Trials in Oncology

Antioch, CA · Arroyo Grande, CA · Burbank, CA · +452 more sites

RecruitingPhase 3NCT04267848

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Sponsor: National Cancer Institute (NCI)

Anaheim, CA · Antioch, CA · Arroyo Grande, CA · +1147 more sites

RecruitingPhase 1 / Phase 2NCT06162221

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

Sponsor: Revolution Medicines, Inc.

Duarte, CA · Irvine, CA · Los Angeles, CA · +26 more sites

RecruitingPhase 2NCT07595874

Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3

Sponsor: City of Hope Medical Center

Corona, CA · Duarte, CA · Huntington Beach, CA · +8 more sites

RecruitingPhase 3NCT07611110

AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

Sponsor: AstraZeneca

Duarte, CA · Irvine, CA · Newport Beach, CA · +25 more sites

RecruitingPhase 3NCT05980949

Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Anaheim, CA · Chino, CA · +145 more sites

RecruitingPhase 1 / Phase 2NCT06810544

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

Sponsor: Tango Therapeutics, Inc.

Irvine, CA · Los Angeles, CA · San Francisco, CA · +12 more sites

RecruitingPhase 2NCT07288034

Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

Sponsor: City of Hope Medical Center

Corona, CA · Duarte, CA · Huntington Beach, CA · +10 more sites

RecruitingPhase 3NCT07391774

Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

Sponsor: National Cancer Institute (NCI)

Auburn, CA · Berkeley, CA · Beverly Hills, CA · +200 more sites

RecruitingPhase 3NCT07674654

A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine

Sponsor: Kallyope Inc.

Colton, CA · Culver City, CA · Encino, CA · +110 more sites

RecruitingPhase 1NCT06545331

Study of XB010 in Subjects With Solid Tumors

Sponsor: Exelixis

Irvine, CA · Los Angeles, CA · +14 more sites

RecruitingPhase 3NCT07177352

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

Sponsor: Hoffmann-La Roche

Imperial, CA · Irvine, CA · Long Beach, CA · +65 more sites

RecruitingPhase 3NCT07028853

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

Sponsor: Pfizer

Alhambra, CA · Atascadero, CA · Beverly Hills, CA · +124 more sites

RecruitingPhase 3NCT06841354

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

Sponsor: Merck Sharp & Dohme LLC

Duarte, CA · Irvine, CA · Los Angeles, CA · +36 more sites

RecruitingNot applicableNCT06898515

Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

Sponsor: Reprieve Cardiovascular, Inc

Irvine, CA · Long Beach, CA · Sacramento, CA · +32 more sites

RecruitingPhase 3NCT06952504

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Sponsor: Merck Sharp & Dohme LLC

Irvine, CA · Orange, CA · Solvang, CA · +50 more sites

RecruitingPhase 3NCT06989112

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Sponsor: AstraZeneca

Duarte, CA · Irvine, CA · La Jolla, CA · +60 more sites

RecruitingPhase 3NCT07128199

A Study to Assess Zipalertinib Versus Placebo in Participants With Early Stage NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection

Sponsor: Taiho Oncology, Inc.

Duarte, CA · Irvine, CA · La Jolla, CA · +27 more sites

RecruitingPhase 3NCT07216703

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

Sponsor: Merck Sharp & Dohme LLC

Irvine, CA · Orange, CA · +28 more sites

RecruitingPhase 3NCT07351045

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

Sponsor: Hoffmann-La Roche

Irvine, CA · San Diego, CA · Walnut Creek, CA · +41 more sites

RecruitingPhase 3NCT07717411

A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease

Sponsor: Hoffmann-La Roche

Irvine, CA · Long Beach, CA · Oakland, CA · +9 more sites

RecruitingPhase 2NCT06031688

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

Sponsor: SWOG Cancer Research Network

Anaheim, CA · Auburn, CA · Baldwin Park, CA · +275 more sites

RecruitingPhase 2 / Phase 3NCT07100080

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

Sponsor: Bristol-Myers Squibb

Irvine, CA · Orange, CA · +26 more sites

RecruitingPhase 2NCT07476287

Symbiotic-Lung-14: A Study to Learn About the Study Medicine Called PF08634404 in Combination With Chemotherapy in Adult Participants With Transformed Small Cell Lung Cancer

Sponsor: Pfizer

Duarte, CA · Encinitas, CA · Irvine, CA · +20 more sites

RecruitingPhase 3NCT06976203

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

Sponsor: Bristol-Myers Squibb

Fullerton, CA · Irvine, CA · Los Angeles, CA · +28 more sites

RecruitingPhase 2NCT07033494

A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

Sponsor: Merck Sharp & Dohme LLC

Irvine, CA · Long Beach, CA · Los Angeles, CA · +33 more sites

RecruitingPhase 3NCT07174336

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Sponsor: Eli Lilly and Company

Clovis, CA · Duarte, CA · Emeryville, CA · +126 more sites

RecruitingPhase 2NCT07589595

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

Sponsor: Eli Lilly and Company

Carlsbad, CA · Irvine, CA · La Jolla, CA · +39 more sites

RecruitingPhase 1NCT07787169

A Master Protocol Studying Multiple Amyloid-Targeting Therapies in Healthy Participants and Participants With Alzheimer's Disease

Sponsor: Eli Lilly and Company

Anaheim, CA · Irvine, CA · Los Alamitos, CA · +10 more sites

RecruitingPhase 1NCT05997615

Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer

Sponsor: Astellas Pharma Global Development, Inc.

Duarte, CA · Irvine, CA · Orange, CA · +5 more sites

RecruitingPhase 3NCT07775300

A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

Sponsor: Eli Lilly and Company

Irvine, CA · Long Beach, CA · Oakland, CA · +31 more sites

RecruitingPhase 3NCT06790693

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Sponsor: Hoffmann-La Roche

Burbank, CA · Irvine, CA · La Jolla, CA · +59 more sites

RecruitingPhase 2NCT07061951

Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

Sponsor: National Cancer Institute (NCI)

Duarte, CA · Irvine, CA · Sacramento, CA · +6 more sites

RecruitingPhase 3NCT07228832

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

Sponsor: Summit Therapeutics

Beverly Hills, CA · Cerritos, CA · +109 more sites

RecruitingPhase 1 / Phase 2NCT05797168

Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors

Sponsor: AstraZeneca

Duarte, CA · Irvine, CA · La Jolla, CA · +10 more sites

RecruitingPhase 2 / Phase 3NCT07005102

A Study to Assess Adverse Events, Change in Disease Activity of Intravenous Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Adult Participants With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

Sponsor: AbbVie

Duarte, CA · Irvine, CA · Los Angeles, CA · +15 more sites

RecruitingPhase 2 / Phase 3NCT07155187

A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

Sponsor: AbbVie

Duarte, CA · Irvine, CA · La Jolla, CA · +13 more sites

RecruitingPhase 1 / Phase 2NCT04585750

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

Sponsor: PMV Pharmaceuticals, Inc

Irvine, CA · La Jolla, CA · Los Angeles, CA · +29 more sites

RecruitingNot applicableNCT05359991

Exercise in Child Health

Sponsor: University of California, Irvine

Irvine, CA

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.