Clinical trials in Orange, CA

105 recruiting studies have a site in or near Orange, CA, California.

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Showing 40 of 105 studies

RecruitingPhase 3NCT03150693

Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

Sponsor: Alliance for Clinical Trials in Oncology

Antioch, CA · Arroyo Grande, CA · Burbank, CA · +452 more sites

RecruitingPhase 3NCT04267848

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Sponsor: National Cancer Institute (NCI)

Anaheim, CA · Antioch, CA · Arroyo Grande, CA · +1147 more sites

RecruitingPhase 2NCT06317662

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

Sponsor: National Cancer Institute (NCI)

Loma Linda, CA · Long Beach, CA · Oakland, CA · +112 more sites

RecruitingPhase 4NCT07221877

A Study to Evaluate the Effect of KarXT on Urological Safety

Sponsor: Bristol-Myers Squibb

Bellflower, CA · Garden Grove, CA · Orange, CA · +13 more sites

RecruitingPhase 3NCT05980949

Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Anaheim, CA · Chino, CA · +145 more sites

RecruitingPhase 3NCT07391774

Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

Sponsor: National Cancer Institute (NCI)

Auburn, CA · Berkeley, CA · Beverly Hills, CA · +200 more sites

RecruitingPhase 3NCT06439082

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

Sponsor: Novartis Pharmaceuticals

Orange, CA · +16 more sites

RecruitingPhase 3NCT06617325

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

Sponsor: UCB Biopharma SRL

Beverly Hills, CA · La Jolla, CA · +60 more sites

RecruitingPhase 3NCT07424404

A Study to Evaluate the Long-term Safety and Tolerability of Xanomeline and Trospium Chloride for the Treatment of Psychiatric Disorders in Children and Adolescents

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Anaheim, CA · Chino, CA · +53 more sites

RecruitingPhase 2NCT07459647

A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia

Sponsor: MapLight Therapeutics

Bellflower, CA · Cerritos, CA · Culver City, CA · +42 more sites

RecruitingPhase 4NCT06581328

A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting

Sponsor: Takeda

Escondido, CA · Murrieta, CA · +98 more sites

RecruitingPhase 3NCT07064473

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

Sponsor: Boehringer Ingelheim

Beverly Hills, CA · Canoga Park, CA · Concord, CA · +205 more sites

RecruitingPhase 3NCT06023589

A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma

Sponsor: AstraZeneca

La Jolla, CA · Long Beach, CA · Orange, CA · +27 more sites

RecruitingPhase 3NCT06307652

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

Sponsor: AstraZeneca

Beverly Hills, CA · Covina, CA · Encinitas, CA · +163 more sites

RecruitingPhase 3NCT06307665

Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma

Sponsor: AstraZeneca

Huntington Beach, CA · Long Beach, CA · +117 more sites

RecruitingPhase 3NCT06430801

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

Sponsor: Merck Sharp & Dohme LLC

Anaheim, CA · Coronado, CA · Lancaster, CA · +84 more sites

RecruitingPhase 3NCT06736574

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

Sponsor: Cytokinetics

Beverly Hills, CA · La Jolla, CA · Loma Linda, CA · +85 more sites

RecruitingPhase 3NCT06952504

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Sponsor: Merck Sharp & Dohme LLC

Irvine, CA · Orange, CA · Solvang, CA · +50 more sites

RecruitingPhase 3NCT07007312

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

Sponsor: Kura Oncology, Inc.

Clovis, CA · La Jolla, CA · Los Angeles, CA · +41 more sites

RecruitingPhase 3NCT07216703

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

Sponsor: Merck Sharp & Dohme LLC

Irvine, CA · Orange, CA · +28 more sites

RecruitingPhase 3NCT06405087

A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Sponsor: Takeda

Loma Linda, CA · Orange, CA · +11 more sites

RecruitingPhase 2 / Phase 3NCT07100080

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

Sponsor: Bristol-Myers Squibb

Irvine, CA · Orange, CA · +26 more sites

RecruitingPhase 2NCT06699849

Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis

Sponsor: CSL Behring

Oakland, CA · Orange, CA · +18 more sites

RecruitingPhase 3NCT07011745

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease

Sponsor: Bristol-Myers Squibb

Garden Grove, CA · Long Beach, CA · +39 more sites

RecruitingPhase 3NCT07174336

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Sponsor: Eli Lilly and Company

Clovis, CA · Duarte, CA · Emeryville, CA · +126 more sites

RecruitingPhase 1NCT05997615

Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer

Sponsor: Astellas Pharma Global Development, Inc.

Duarte, CA · Irvine, CA · Orange, CA · +5 more sites

RecruitingPhase 3NCT06672549

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

Sponsor: Eli Lilly and Company

Loma Linda, CA · Los Angeles, CA · +47 more sites

RecruitingPhase 2NCT06847321

Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease

Sponsor: Lighthouse Pharmaceuticals, Inc.

Murrieta, CA · Oakland, CA · Orange, CA · +36 more sites

RecruitingPhase 1 / Phase 2NCT06121297

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

Sponsor: Cabaletta Bio

Orange, CA · Sacramento, CA · +19 more sites

RecruitingPhase 3NCT07228832

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

Sponsor: Summit Therapeutics

Beverly Hills, CA · Cerritos, CA · +109 more sites

RecruitingPhase 2NCT07284667

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

Sponsor: ACADIA Pharmaceuticals Inc.

Chino, CA · Glendale, CA · La Jolla, CA · +25 more sites

RecruitingPhase 2NCT05673148

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

Sponsor: Alliance for Clinical Trials in Oncology

Beverly Hills, CA · Irvine, CA · Los Angeles, CA · +185 more sites

RecruitingPhase 3NCT07200830

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

Sponsor: Alliance for Clinical Trials in Oncology

Bakersfield, CA · Irvine, CA · +135 more sites

RecruitingPhase 2NCT07304011

Olutasidenib With Azacitidine Followed by Olutasidenib Maintenance for the Treatment of IDH1-mutated Acute Myeloid Leukemia in Patients With Prior Treatment With Venetoclax Plus a Hypomethylating Agent

Sponsor: University of California, Davis

Orange, CA · Sacramento, CA

RecruitingPhase 2NCT06887192

A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis

Sponsor: MapLight Therapeutics

Anaheim, CA · Long Beach, CA · Murrieta, CA · +34 more sites

RecruitingPhase not listedNCT07101094

Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

Sponsor: Bristol-Myers Squibb

Orange, CA · San Jose, CA · +18 more sites

RecruitingPhase 2NCT06540833

A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease

Sponsor: Intra-Cellular Therapies, Inc.

Anaheim, CA · Los Alamitos, CA · Newport Beach, CA · +25 more sites

RecruitingPhase 3NCT05646862

A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy

Sponsor: Hoffmann-La Roche

Greenbrae, CA · Los Alamitos, CA · Los Angeles, CA · +36 more sites

RecruitingPhase 3NCT07277231

A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia

Sponsor: BeOne Medicines

Duarte, CA · Orange, CA · Palo Alto, CA · +19 more sites

RecruitingPhase 3NCT07686263

Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Anaheim, CA · Bellflower, CA · Chino, CA · +31 more sites

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.