Recently updated clinical trials

The 50 recruiting studies most recently updated by their teams on ClinicalTrials.gov. Updates can mean new sites, changed eligibility or a new status.

Updated 2026-10-20

RecruitingPhase 1 / Phase 2NCT03109288

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Bethesda, MD

Updated 2026-10-20

RecruitingPhase 3NCT04047628

Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Palo Alto, CA · Aurora, CO · Evanston, IL · +20 more sites

Updated 2026-10-20

RecruitingPhase 1NCT05003388

Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for MS

Sponsor: The Foundation for Orthopaedics and Regenerative Medicine

Naples, FL

Updated 2026-10-20

Not yet recruitingNot applicableNCT05509842

Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD)

Sponsor: University of Michigan

Ann Arbor, MI

Updated 2026-10-20

RecruitingNot applicableNCT06067451

SMART GOALS for Youth With Prediabetes

Sponsor: Northwell Health

New York, NY

Updated 2026-10-20

RecruitingNot applicableNCT06169852

Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD

Sponsor: University of Alabama at Birmingham

Birmingham, AL

Updated 2026-10-20

RecruitingPhase 3NCT06345729

A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Sponsor: Merck Sharp & Dohme LLC

Bakersfield, CA · Beverly Hills, CA · Stamford, CT · +12 more sites

Updated 2026-10-20

RecruitingPhase 3NCT07067463

A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis

Sponsor: Zenas BioPharma (USA), LLC

Pheonix, AZ · Scottsdale, AZ · West Hollywood, CA · +16 more sites

Updated 2026-10-20

RecruitingPhase 3NCT07654374

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

Birmingham, AL · Chandler, AZ · Phoenix, AZ · +71 more sites

Updated 2026-10-20

RecruitingPhase 2NCT07752979

Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

Sponsor: AbbVie

Pelham, AL · Scottsdale, AZ · Tucson, AZ · +56 more sites

Updated 2026-10-20

Not yet recruitingPhase 1NCT07883590

A Study of LY3873862 in Participants With Sporadic or Familial Amyotrophic Lateral Sclerosis (ALS).

Sponsor: Eli Lilly and Company

San Francisco, CA · Aurora, CO · Kansas City, KS

Updated 2026-10-20

RecruitingNot applicableNCT07883720

EXercise-induced PhysioLogical Adaptations In Neurological Disorders

Sponsor: Brigham and Women's Hospital

Boston, MA

Updated 2026-10-19

RecruitingPhase not listedNCT02769975

Evaluation of Children With Endocrine and Metabolic-Related Conditions

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Bethesda, MD

Updated 2026-10-19

RecruitingPhase 3NCT03150693

Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

Sponsor: Alliance for Clinical Trials in Oncology

Birmingham, AL · Anchorage, AK · +452 more sites

Updated 2026-10-19

RecruitingPhase 3NCT03394365

A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

Sponsor: Pierre Fabre Medicament

Duarte, CA · La Jolla, CA · Loma Linda, CA · +37 more sites

Updated 2026-10-19

RecruitingPhase 3NCT04267848

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Sponsor: National Cancer Institute (NCI)

Anchorage, AK · +1147 more sites

Updated 2026-10-19

RecruitingPhase 1 / Phase 2NCT04977453

GI-101/GI-101A as a Single Agent or in Combination With Pembrolizumab or Lenvatinib in Advanced Solid Tumors

Sponsor: GI Innovation, Inc.

New York, NY · Huntersville, NC

Updated 2026-10-19

RecruitingPhase not listedNCT05213572

Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Bethesda, MD

Updated 2026-10-19

RecruitingPhase 2NCT05873192

Presurgical Phase II Study of Talazoparib in Combination With Enzalutamide in Prostate Cancer

Sponsor: M.D. Anderson Cancer Center

Houston, TX

Updated 2026-10-19

RecruitingPhase 1 / Phase 2NCT06162221

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

Sponsor: Revolution Medicines, Inc.

Gilbert, AZ · Duarte, CA · Irvine, CA · +26 more sites

Updated 2026-10-19

RecruitingPhase 2NCT06317662

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

Sponsor: National Cancer Institute (NCI)

Birmingham, AL · Anchorage, AK · Mesa, AZ · +112 more sites

Updated 2026-10-19

RecruitingPhase 3NCT06498635

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

Sponsor: National Cancer Institute (NCI)

Jonesboro, AR · Beverly Hills, CA · Dublin, CA · +278 more sites

Updated 2026-10-19

RecruitingNot applicableNCT06524856

The Increase of Lung Capacity Using the Lung Master (Pulmonary Exerciser)

Sponsor: University of Nebraska

Omaha, NE

Updated 2026-10-19

RecruitingPhase 1NCT06575296

Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant

Sponsor: City of Hope Medical Center

Duarte, CA

Updated 2026-10-19

Not yet recruitingPhase not listedNCT06690294

Assessing the Impact of Perceptions of Unpredictability on Objective Measures of Food Consumption and Metabolism

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Phoenix, AZ

Updated 2026-10-19

RecruitingNot applicableNCT06693310

STOP-UC: De-escalation of Therapy in Patients With Ulcerative Colitis With Histological Remission

Sponsor: University of Chicago

Chicago, IL

Updated 2026-10-19

RecruitingPhase 3NCT06763328

Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

Sponsor: City of Hope Medical Center

Duarte, CA · La Jolla, CA · Riverside, CA

Updated 2026-10-19

RecruitingNot applicableNCT06891755

Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

Sponsor: Apreo Health, Inc.

Birmingham, AL · Gilbert, AZ · Sacramento, CA · +15 more sites

Updated 2026-10-19

RecruitingPhase 1NCT06904066

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

Sponsor: National Cancer Institute (NCI)

Bethesda, MD

Updated 2026-10-19

RecruitingPhase 1NCT06916806

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.

Sponsor: AstraZeneca

Anniston, AL · Birmingham, AL · La Jolla, CA · +4 more sites

Updated 2026-10-19

RecruitingPhase not listedNCT06948110

Deciphering the Genetic Architecture of Autoimmune Diseases

Sponsor: National Human Genome Research Institute (NHGRI)

Bethesda, MD

Updated 2026-10-19

RecruitingPhase 4NCT06972056

Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

Sponsor: Mayo Clinic

Hazel Green, AL · Flagstaff, AZ · Phoenix, AZ · +34 more sites

Updated 2026-10-19

RecruitingPhase 2NCT06976619

The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes

Sponsor: Mayo Clinic

Rochester, MN

Updated 2026-10-19

RecruitingNot applicableNCT07042217

Transcranial Direct Current Stimulation for Depression

Sponsor: Soterix Medical

Woodbridge, NJ

Updated 2026-10-19

RecruitingPhase 3NCT07071519

A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis

Sponsor: AbbVie

Phoenix, AZ · San Diego, CA · San Francisco, CA · +9 more sites

Updated 2026-10-19

RecruitingPhase 4NCT07133880

Compare the Effects of Nebulizer Versus Inhaler Based Therapy for COPD Using Long-acting Bronchodilators

Sponsor: University of Tennessee Graduate School of Medicine

Knoxville, TN

Updated 2026-10-19

RecruitingPhase 1NCT07169630

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

Sponsor: National Institute of Mental Health (NIMH)

Bethesda, MD

Updated 2026-10-19

Not yet recruitingPhase 4NCT07187466

Behavioral and/or Mirabegron to Treat Urinary Symptoms in Parkinson Disease

Sponsor: VA Office of Research and Development

Decatur, GA · Philadelphia, PA · Salt Lake City, UT

Updated 2026-10-19

RecruitingPhase 3NCT07190209

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype

Sponsor: Sanofi

Chandler, AZ · Phoenix, AZ · Surprise, AZ · +72 more sites

Updated 2026-10-19

RecruitingPhase 4NCT07221877

A Study to Evaluate the Effect of KarXT on Urological Safety

Sponsor: Bristol-Myers Squibb

Little Rock, AR · Bellflower, CA · Garden Grove, CA · +13 more sites

Updated 2026-10-19

RecruitingPhase 2NCT07281456

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)

Bethesda, MD

Updated 2026-10-19

RecruitingPhase 1NCT07304154

Study of KITE-363 in Participants With Autoimmune Neurologic Diseases That Did Not Respond to Usual Treatment

Sponsor: Kite, A Gilead Company

Newport Beach, CA · Palo Alto, CA · New York, NY · +2 more sites

Updated 2026-10-19

RecruitingPhase 3NCT07404865

Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease

Sponsor: Vor Biopharma

Chandler, AZ · Flagstaff, AZ · Glendale, AZ · +44 more sites

Updated 2026-10-19

RecruitingPhase 1NCT07509034

Autologous B7-H3 Chimeric Antigen Receptor T Cells in Previously Treated Extensive-Stage Small Cell Lung Cancer With Recurrent or Refractory Disease

Sponsor: National Cancer Institute (NCI)

Bethesda, MD

Updated 2026-10-19

RecruitingPhase 3NCT07513376

A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)

Sponsor: Merck Sharp & Dohme LLC

Sacramento, CA · Aurora, CO · New Haven, CT · +21 more sites

Updated 2026-10-19

RecruitingPhase 3NCT07525206

A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer

Sponsor: AbbVie

Goodyear, AZ · Springdale, AR · Duarte, CA · +15 more sites

Updated 2026-10-19

RecruitingPhase 2NCT07527650

Study to Evaluate HM15275 in Subjects With Type 2 Diabetes Mellitus

Sponsor: Hanmi Pharmaceutical Company Limited

Mesa, AZ · Santa Clarita, CA · DeLand, FL · +17 more sites

Updated 2026-10-19

RecruitingPhase 2NCT07595874

Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3

Sponsor: City of Hope Medical Center

Goodyear, AZ · Corona, CA · Duarte, CA · +8 more sites

Updated 2026-10-19

RecruitingPhase not listedNCT07619547

Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Bethesda, MD

Updated 2026-10-19

Not yet recruitingPhase not listedNCT07647549

Pulmonary Hypertension (PH) Biorepository for Translational Research

Sponsor: National Institutes of Health Clinical Center (CC)

Baltimore, MD · Bethesda, MD · Falls Church, VA

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.