Phase 3 Sickle Cell Disease clinical trials

9 recruiting Phase 3 sickle cell disease studies in the US. What trial phases mean

Other phases

RecruitingPhase 3NCT06439082

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

Sponsor: Novartis Pharmaceuticals

Birmingham, AL · Orange, CA · Washington D.C., DC · +14 more sites

RecruitingPhase 3NCT06975865

The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease

Sponsor: Sanofi

Birmingham, AL · Phoenix, AZ · Clovis, CA · +18 more sites

RecruitingPhase 3NCT07656415

A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)

Sponsor: Agios Pharmaceuticals, Inc.

Indianapolis, IN · Grand Rapids, MI · Flowood, MS

RecruitingPhase 3NCT06609226

A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

Sponsor: Novo Nordisk A/S

Birmingham, AL · Phoenix, AZ · Los Angeles, CA · +36 more sites

RecruitingPhase 3NCT06612268

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

Sponsor: Novo Nordisk A/S

Birmingham, AL · Mobile, AL · Phoenix, AZ · +47 more sites

RecruitingPhase 3NCT07247188

Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease

Sponsor: Sanofi

Atlanta, GA · Omaha, NE · +2 more sites

RecruitingPhase 3NCT05477563

Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

Sponsor: Vertex Pharmaceuticals Incorporated

New York, NY · Charlotte, NC · Nashville, TN

Not yet recruitingPhase 3NCT07450430

Optimal Timing of Ketamine Initiation for SCD Pain

Sponsor: Boston Children's Hospital

Brookline, MA

Not yet recruitingPhase 3NCT06989567

A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis

Sponsor: Asklepion Pharmaceuticals, LLC

Washington D.C., DC · Coral Gables, FL · Atlanta, GA · +3 more sites

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.