Clinical trials in Springfield, IL

47 recruiting studies have a site in or near Springfield, IL, Illinois.

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Showing 40 of 47 studies

RecruitingPhase 3NCT04267848

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Sponsor: National Cancer Institute (NCI)

Alton, IL · Aurora, IL · Barrington, IL · +1147 more sites

RecruitingPhase 2NCT06317662

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

Sponsor: National Cancer Institute (NCI)

Chicago, IL · Oak Lawn, IL · +112 more sites

RecruitingPhase 2NCT05554393

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

Sponsor: National Cancer Institute (NCI)

Centralia, IL · Chicago, IL · +172 more sites

RecruitingPhase not listedNCT06297291

Global Paradise System US Post Approval Study

Sponsor: ReCor Medical, Inc.

Springfield, IL · +45 more sites

RecruitingPhase 3NCT07388524

Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial

Sponsor: National Cancer Institute (NCI)

Bloomington, IL · Canton, IL · Carthage, IL · +97 more sites

RecruitingPhase 3NCT07391774

Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

Sponsor: National Cancer Institute (NCI)

Bloomington, IL · Canton, IL · Carterville, IL · +200 more sites

RecruitingNot applicableNCT07005050

Renal Pelvic Denervation Pilot Trial

Sponsor: Verve Medical, Inc

Springfield, IL · +8 more sites

RecruitingPhase 3NCT07181109

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

Sponsor: Alnylam Pharmaceuticals

Arlington Heights, IL · Chicago, IL · +270 more sites

RecruitingPhase 2NCT06317649

Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

Sponsor: National Cancer Institute (NCI)

Chicago, IL · +222 more sites

RecruitingPhase 4NCT06581328

A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting

Sponsor: Takeda

Downers Grove, IL · Glenview, IL · Lake Barrington, IL · +98 more sites

RecruitingPhase 3NCT06935370

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

Sponsor: Boehringer Ingelheim

Arlington Heights, IL · Hazel Crest, IL · Libertyville, IL · +86 more sites

RecruitingPhase 1NCT07310420

A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer

Sponsor: TerSera Therapeutics LLC

Chicago, IL · Evanston, IL · Lisle, IL · +23 more sites

RecruitingPhase 2NCT06031688

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

Sponsor: SWOG Cancer Research Network

Bloomington, IL · Canton, IL · Carthage, IL · +275 more sites

RecruitingPhase 3NCT06878261

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

Sponsor: AstraZeneca

Evanston, IL · Hinsdale, IL · Springfield, IL · +77 more sites

RecruitingPhase 3NCT06976203

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

Sponsor: Bristol-Myers Squibb

Chicago, IL · Springfield, IL · +29 more sites

RecruitingPhase 3NCT07037433

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Sponsor: Amgen

Arlington Heights, IL · Chicago, IL · +137 more sites

RecruitingPhase 3NCT07174336

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Sponsor: Eli Lilly and Company

Chicago, IL · +126 more sites

RecruitingPhase 2NCT07415044

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

Sponsor: Eli Lilly and Company

Chicago, IL · Des Plaines, IL · +49 more sites

RecruitingPhase not listedNCT03998202

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

Sponsor: Wake Forest University Health Sciences

Bloomington, IL · Canton, IL · Carterville, IL · +144 more sites

RecruitingPhase 3NCT06119581

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

Sponsor: Eli Lilly and Company

Chicago, IL · Springfield, IL · +84 more sites

RecruitingPhase 3NCT06790693

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Sponsor: Hoffmann-La Roche

O'Fallon, IL · Springfield, IL · Urbana, IL · +59 more sites

RecruitingNot applicableNCT07283939

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

Sponsor: Alliance for Clinical Trials in Oncology

Alton, IL · Bloomington, IL · Canton, IL · +357 more sites

RecruitingPhase 2NCT06548542

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

Sponsor: AbbVie

Chicago, IL · Peoria, IL · Springfield, IL · +61 more sites

RecruitingNot applicableNCT06559891

THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension

Sponsor: SoniVie Inc.

Elk Grove Village, IL · Springfield, IL · +31 more sites

RecruitingNot applicableNCT04592445

Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

Sponsor: Axon Therapies, Inc.

Chicago, IL · Springfield, IL · +21 more sites

RecruitingPhase 3NCT04293562

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

Sponsor: Children's Oncology Group

Chicago, IL · +183 more sites

RecruitingPhase 1 / Phase 2NCT06783309

CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)

Sponsor: COUR Pharmaceutical Development Company, Inc.

Chicago, IL · Springfield, IL · +42 more sites

RecruitingPhase 3NCT05879926

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

Sponsor: NRG Oncology

Alton, IL · Aurora, IL · +1223 more sites

RecruitingPhase 3NCT06072612

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

Sponsor: BriaCell Therapeutics Corporation

Chicago, IL · Springfield, IL · Urbana, IL · +76 more sites

RecruitingPhase 1 / Phase 2NCT04726241

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

Sponsor: PedAL BCU, LLC

Chicago, IL · +161 more sites

RecruitingPhase 1NCT06001788

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Sponsor: Kura Oncology, Inc.

Chicago, IL · Maywood, IL · Springfield, IL · +35 more sites

RecruitingPhase 3NCT04423211

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Sponsor: ECOG-ACRIN Cancer Research Group

Alton, IL · Aurora, IL · +338 more sites

RecruitingNot applicableNCT05685303

Alleviant ALLAY-HF Study

Sponsor: Alleviant Medical, Inc.

Chicago, IL · Naperville, IL · Springfield, IL · +53 more sites

RecruitingPhase 3NCT06801834

Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer

Sponsor: Gilead Sciences

Hinsdale, IL · Springfield, IL · +20 more sites

RecruitingPhase 3NCT05812807

Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

Sponsor: Alliance for Clinical Trials in Oncology

Aurora, IL · Barrington, IL · +825 more sites

RecruitingPhase 3NCT06748222

E-Mindfulness Approaches for Living After Breast Cancer

Sponsor: NRG Oncology

Arlington Heights, IL · Aurora, IL · Bloomington, IL · +378 more sites

RecruitingPhase 1NCT04389632

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Calumet City, IL · Chicago, IL · +103 more sites

RecruitingNot applicableNCT03887715

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Sponsor: LivaNova

Chicago, IL · Joliet, IL · Naperville, IL · +98 more sites

RecruitingPhase 2NCT05642572

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

Sponsor: SWOG Cancer Research Network

Barrington, IL · Bloomington, IL · Canton, IL · +451 more sites

RecruitingPhase 2 / Phase 3NCT03851445

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Sponsor: SWOG Cancer Research Network

Alton, IL · Aurora, IL · +1226 more sites

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.