RecruitingPhase 2NCT07721467
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Sponsor: National Institute on Aging (NIA)
Baltimore, MD
Phase 2 Alzheimer's Disease clinical trials
48 recruiting Phase 2 alzheimer's disease studies in the US. What trial phases mean
Other phases
RecruitingPhase 2NCT07236190
Biomarker-based Trial of NPC-1 for Alzheimer's Pathology
Sponsor: Massachusetts General Hospital
Boston, MA
RecruitingPhase 2NCT07636811
A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)
Sponsor: Alnylam Pharmaceuticals
Maitland, FL · Naples, FL · Indianapolis, IN · +1 more sites
RecruitingPhase 2NCT06052254
Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type
Sponsor: Teikoku Pharma USA, Inc.
Chino, CA · Daytona Beach, FL · Delray Beach, FL · +7 more sites
RecruitingPhase 2NCT07033494
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
Sponsor: Merck Sharp & Dohme LLC
Irvine, CA · Long Beach, CA · Los Angeles, CA · +33 more sites
RecruitingPhase 2NCT07589595
A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
Sponsor: Eli Lilly and Company
Chandler, AZ · Scottsdale, AZ · Carlsbad, CA · +39 more sites
RecruitingPhase 2NCT06847321
Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease
Sponsor: Lighthouse Pharmaceuticals, Inc.
Phoenix, AZ · Scottsdale, AZ · +36 more sites
RecruitingPhase 2NCT06808984
Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
Sponsor: Celgene
Homewood, AL · Huntsville, AL · Phoenix, AZ · +57 more sites
RecruitingPhase 2NCT06887192
A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis
Sponsor: MapLight Therapeutics
Phoenix, AZ · Scottsdale, AZ · Tucson, AZ · +34 more sites
RecruitingPhase 2NCT06540833
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease
Sponsor: Intra-Cellular Therapies, Inc.
Anaheim, CA · Los Alamitos, CA · Newport Beach, CA · +25 more sites
RecruitingPhase 2NCT06651567
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia
Sponsor: Intra-Cellular Therapies, Inc.
Anaheim, CA · Costa Mesa, CA · Garden Grove, CA · +28 more sites
RecruitingPhase 2NCT07794670
Randomized Study to Evaluate the Effect of Obicetrapib in Participants With Preclinical Alzheimer's Disease
Sponsor: NewAmsterdam Pharma
Nashville, TN
RecruitingPhase 2NCT06041789
Effect of Acetylcholinesterase Inhibitors on Bone Metabolism
Sponsor: Duke University
Durham, NC
RecruitingPhase 2NCT06957418
Alzheimer's Tau Platform: Master Protocol
Sponsor: Paul S. Aisen
San Francisco, CA · Providence, RI · Nashville, TN
RecruitingPhase 2NCT06514001
A Study of AMDX-2011P in Participants With Alzheimer's Disease
Sponsor: Amydis Inc.
Phoenix, AZ
RecruitingPhase 2NCT07764185
Caring Recharge Project for Caregivers of Individuals With Alzheimer's Disease
Sponsor: Photozig, Inc.
Campbell, CA
RecruitingPhase 2NCT04804241
Senicapoc in Alzheimer's Disease
Sponsor: University of California, Davis
Sacramento, CA · Walnut Creek, CA
RecruitingPhase 2NCT03503331
UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy
Sponsor: University of Alabama at Birmingham
Birmingham, AL
RecruitingPhase 2NCT05446584
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
Sponsor: University of Texas Southwestern Medical Center
Dallas, TX
RecruitingPhase 2NCT04601038
Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
Sponsor: Johns Hopkins University
Baltimore, MD
RecruitingPhase 2NCT04629547
Sleep Trial to Prevent Alzheimer's Disease
Sponsor: University of Minnesota
St Louis, MO
RecruitingPhase 2NCT06274528
DORA and LP in Alzheimer's Disease Biomarkers
Sponsor: University of Minnesota
St Louis, MO
RecruitingPhase 2NCT04576793
Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
Sponsor: Columbia University
New York, NY
RecruitingPhase 2NCT07094516
A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
Sponsor: Novartis Pharmaceuticals
Phoenix, AZ · Irvine, CA · La Jolla, CA · +21 more sites
RecruitingPhase 2NCT05231798
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
Sponsor: Vanderbilt University Medical Center
Nashville, TN
RecruitingPhase 2NCT05282550
Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone
Sponsor: Johns Hopkins University
Baltimore, MD
RecruitingPhase 2NCT06191198
Communication Bridge 3 Study
Sponsor: University of Chicago
Chicago, IL
RecruitingPhase 2NCT06781333
Human Mesenchymal Stem Cells (hMSC) in Behavioral Problems Due to Alzheimer's Disease.
Sponsor: Bernard (Barry) Baumel
Miami, FL
RecruitingPhase 2NCT07512362
Human Mesenchymal Stem Cells & Monoclonal Antibodies in the Treatment for Mild Cognitive Impairment or Early Alzheimer's Disease.
Sponsor: Bernard (Barry) Baumel
Miami, FL
RecruitingPhase 2NCT07553338
Safety Assessment of Leronlimab and Its Effect on Brain Inflammation in Alzheimer's Disease
Sponsor: Weill Medical College of Cornell University
New York, NY
RecruitingPhase 2NCT04902703
Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease
Sponsor: University of Colorado, Denver
Aurora, CO
RecruitingPhase 2NCT07012993
Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol
Sponsor: Akiva Mintz
Englewood, NJ
RecruitingPhase 2NCT06639282
Repurposing Siponimod for Alzheimer's Disease
Sponsor: St. Joseph's Hospital and Medical Center, Phoenix
Phoenix, AZ
RecruitingPhase 2NCT05597124
Exercise to Improve Brain Health in Older African Americans
Sponsor: Rutgers, The State University of New Jersey
Newark, NJ
RecruitingPhase 2NCT06489548
Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease
Sponsor: Brigham and Women's Hospital
Boston, MA
RecruitingPhase 2NCT07392723
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
Sponsor: Michal Schnaider Beeri, Ph.D.
New Brunswick, NJ
RecruitingPhase 2NCT07105709
Open-label Extension Study in Participants With Early Alzheimer's Disease
Sponsor: GlaxoSmithKline
Maitland, FL · Miami, FL · Stuart, FL · +6 more sites
RecruitingPhase 2NCT06052163
Bumetanide in Patients With Alzheimer's Disease
Sponsor: Stanford University
Stanford, CA
RecruitingPhase 2NCT07217912
Daridorexant to Prevent Post-cardiotomy Delirium
Sponsor: University of Rochester
Rochester, NY
RecruitingPhase 2NCT07228078
Open-Label Extension Protocol to SNK01-AD01 Study
Sponsor: NKGen Biotech, Inc.
Glendale, CA
RecruitingPhase 2NCT05565833
Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
Sponsor: University of Virginia
Charlottesville, VA
RecruitingPhase 2NCT04436081
Effects of THC-Free CBD Oil on Agitation in Patients With Alzheimer's Disease
Sponsor: Eastern Virginia Medical School
Norfolk, VA
Not yet recruitingPhase 2NCT07868718
Peer Support for Family Caregivers of Older Adults Living With Dementia
Sponsor: Ohio State University
Columbus, OH
Not yet recruitingPhase 2NCT07873463
Flutemetamol F 18 Injection Formulation Comparison
Sponsor: GE Healthcare
Aventura, FL · Merritt Island, FL · Miami, FL · +3 more sites
Not yet recruitingPhase 2NCT07781657
Study to Test Effects and Safety of RO7568282 in Early Symptomatic Alzheimer's Disease
Sponsor: Hoffmann-La Roche
Laurelton, NY
Not yet recruitingPhase 2NCT07756294
Restoring Vascular and Insulin Function To Augment Anti-Amyloid Therapy in Alzheimer's Disease
Sponsor: Wake Forest University Health Sciences
Winston-Salem, NC
Not yet recruitingPhase 2NCT07796308
Terazosin And Metabolic Engagement in Alzheimer's Disease
Sponsor: Qiang Zhang
Iowa City, IA
Not yet recruitingPhase 2NCT06470061
RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β
Sponsor: Zaparackas and Knepper LTD
Chicago, IL
Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.