RecruitingPhase 1NCT07169630
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
Sponsor: National Institute of Mental Health (NIMH)
Bethesda, MD
Phase 1 Alzheimer's Disease clinical trials
25 recruiting Phase 1 alzheimer's disease studies in the US. What trial phases mean
Other phases
RecruitingPhase 1NCT07787169
A Master Protocol Studying Multiple Amyloid-Targeting Therapies in Healthy Participants and Participants With Alzheimer's Disease
Sponsor: Eli Lilly and Company
Anaheim, CA · Irvine, CA · Los Alamitos, CA · +10 more sites
RecruitingPhase 1NCT07413744
The Gut - PRO Study
Sponsor: University of Wisconsin, Madison
Madison, WI
RecruitingPhase 1NCT07598370
A Study of LY3439539 in Participants With Alzheimer's Disease
Sponsor: Eli Lilly and Company
Irvine, CA · Long Beach, CA · Los Angeles, CA · +5 more sites
RecruitingPhase 1NCT07780383
A Study to Evaluate the Drug Levels, Absolute Bioavailability, Safety, Tolerability, and Immunogenicity of Single-Dose of BMS-986446 in Healthy Adults After Single-dose Administration, and Participants With Early Alzheimer's Disease After Multiple Dose Administration
Sponsor: Bristol-Myers Squibb
Anaheim, CA · Bradenton, FL · Daytona Beach, FL · +3 more sites
RecruitingPhase 1NCT04396873
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
Sponsor: National Institute of Mental Health (NIMH)
Bethesda, MD
RecruitingPhase 1NCT05231785
A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD
Sponsor: Alnylam Pharmaceuticals
La Jolla, CA · Indianapolis, IN
RecruitingPhase 1NCT06999434
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
Sponsor: Yale University
New Haven, CT
RecruitingPhase 1NCT07386730
A Study of Psychedelics in Healthy Older Adults With Low Well-being
Sponsor: Jennifer Mitchell
San Francisco, CA
RecruitingPhase 1NCT07764146
An Open Label Dose Escalation Study of VY1706 in Participants With Early Alzheimer's Disease
Sponsor: Voyager Therapeutics
Maitland, FL
RecruitingPhase 1NCT06297590
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
Sponsor: Eli Lilly and Company
Maitland, FL · The Villages, FL · Decatur, GA · +3 more sites
RecruitingPhase 1NCT07158905
AV-1980R (Tau Vaccine) in Preclinical Alzheimer's Disease (TAURUS-1980)
Sponsor: Institute for Molecular Medicine
Boca Raton, FL · Miami Lakes, FL · Stuart, FL · +3 more sites
RecruitingPhase 1NCT06657768
A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)
Sponsor: Eli Lilly and Company
Los Alamitos, CA · Lady Lake, FL · Maitland, FL · +8 more sites
RecruitingPhase 1NCT06372821
A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK
Sponsor: University College, London
St Louis, MO
RecruitingPhase 1NCT05606341
Innate Immunity Stimulation Via TLR9 in Early AD
Sponsor: NYU Langone Health
New York, NY
RecruitingPhase 1NCT07218081
A Trial to Test Intermittent Deep Brain Stimulation of Nucleus Basalis of Meynert to Treat Alzheimers.
Sponsor: Augusta University
Augusta, GA
RecruitingPhase 1NCT06945614
Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation to Control Neuroinflammation
Sponsor: General Biophysics LLC
Boston, MA
RecruitingPhase 1NCT05591027
Safety and Target Engagement of Centella Asiatica in Cognitive Impairment
Sponsor: Oregon Health and Science University
Portland, OR
Not yet recruitingPhase 1NCT07843459
A Study of LY4560736 in Healthy Participants and Participants With Alzheimer's Disease (AD)
Sponsor: Eli Lilly and Company
Anaheim, CA · Irvine, CA · Los Alamitos, CA · +10 more sites
Not yet recruitingPhase 1NCT07531940
Escalating Doses of Memantine in Down Syndrome (MEDS-123)
Sponsor: University Hospitals Cleveland Medical Center
Cleveland, OH
Not yet recruitingPhase 1NCT07787182
A Study of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease
Sponsor: Eli Lilly and Company
Anaheim, CA · Irvine, CA · Los Alamitos, CA · +10 more sites
Not yet recruitingPhase 1NCT07795307
Repurposing a Combination Antiretroviral Drug Therapy to Target Retrotransposons and Treat Early Alzheimer's Disease
Sponsor: Brigham and Women's Hospital
Boston, MA
Not yet recruitingPhase 1NCT07278492
NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome
Sponsor: Brigham and Women's Hospital
Boston, MA
Not yet recruitingPhase 1NCT06600880
Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau
Sponsor: Columbia University
New York, NY
Not yet recruitingPhase 1NCT06644573
Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
Sponsor: Nyree Penn
Aventura, FL
Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.