RecruitingPhase 1NCT04222413
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
Sponsor: National Cancer Institute (NCI)
Fairway, KS · Bethesda, MD
Phase 1 Breast Cancer clinical trials
64 recruiting Phase 1 breast cancer studies in the US. What trial phases mean
Other phases
RecruitingPhase 1NCT06465069
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
Sponsor: Eli Lilly and Company
Duarte, CA · La Jolla, CA · Los Angeles, CA · +20 more sites
RecruitingPhase 1NCT07137416
Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer
Sponsor: National Cancer Institute (NCI)
Boston, MA · St Louis, MO
RecruitingPhase 1NCT06120283
BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors
Sponsor: BeOne Medicines
Denver, CO · Lake Mary, FL · Detroit, MI · +6 more sites
RecruitingPhase 1NCT06545331
Study of XB010 in Subjects With Solid Tumors
Sponsor: Exelixis
Irvine, CA · Los Angeles, CA · Washington D.C., DC · +13 more sites
RecruitingPhase 1NCT05111561
Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer
Sponsor: National Cancer Institute (NCI)
Boston, MA · Galveston, TX · +1 more sites
RecruitingPhase 1NCT07310420
A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer
Sponsor: TerSera Therapeutics LLC
Hot Springs, AR · Washington D.C., DC · Ocoee, FL · +23 more sites
RecruitingPhase 1NCT07261631
Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors
Sponsor: Novartis Pharmaceuticals
Princeton, NJ
RecruitingPhase 1NCT07311993
Phase 1 Study of CLR 125 in Triple Negative Breast Cancer
Sponsor: Cellectar Biosciences, Inc.
Jacksonville, FL · Glen Burnie, MD · Rochester, MN · +1 more sites
RecruitingPhase 1NCT07114601
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Sponsor: Eli Lilly and Company
Duarte, CA · Santa Monica, CA · Stanford, CA · +13 more sites
RecruitingPhase 1NCT06545682
Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA)
Sponsor: M.D. Anderson Cancer Center
Houston, TX
RecruitingPhase 1NCT06840886
A Study of PHST001 in Advanced Solid Tumors
Sponsor: Pheast Therapeutics
Beverly Hills, CA · Los Angeles, CA · Palo Alto, CA · +17 more sites
RecruitingPhase 1NCT07454642
AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors
Sponsor: Avacta Life Sciences Ltd
Scottsdale, AZ · Sarasota, FL · Chicago, IL · +4 more sites
RecruitingPhase 1NCT06270706
A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
Sponsor: Pliant Therapeutics, Inc.
New Haven, CT · Atlanta, GA · Grand Rapids, MI · +13 more sites
RecruitingPhase 1NCT05877599
A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
Sponsor: AstraZeneca
Gilbert, AZ · Duarte, CA · Los Angeles, CA · +17 more sites
RecruitingPhase 1NCT07578571
A Phase 1 Study of IM-1617 in Participants With Advanced Cancer
Sponsor: Immunome, Inc.
New Haven, CT · Sarasota, FL · Boston, MA · +1 more sites
RecruitingPhase 1NCT07222267
An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors
Sponsor: BeOne Medicines
Birmingham, AL · New Haven, CT · St Louis, MO · +3 more sites
RecruitingPhase 1NCT07229313
A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors
Sponsor: Kivu Bioscience Inc.
Santa Monica, CA · New Have, CT
RecruitingPhase 1NCT06999798
An Optimized Ultrasound Twinkling Marker for the Imaging of Lymph Nodes in Patients With Clinically Node-Positive Breast Cancer, The UTMOST2 Trial
Sponsor: Mayo Clinic
Rochester, MN
RecruitingPhase 1NCT05983432
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
Sponsor: SystImmune Inc.
Beverly Hills, CA · Duarte, CA · Orange, CA · +19 more sites
RecruitingPhase 1NCT07020117
A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors
Sponsor: Aktis Oncology, Inc.
Duarte, CA · Irvine, CA · Miami, FL · +11 more sites
RecruitingPhase 1NCT06440005
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
Sponsor: Angiex, Inc.
Los Angeles, CA · Sarasota, FL · St Louis, MO · +4 more sites
RecruitingPhase 1NCT06458712
Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies
Sponsor: Duke Street Bio Ltd
Sacramento, CA · New Haven, CT · New York, NY · +1 more sites
RecruitingPhase 1NCT06488378
Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer
Sponsor: Dana-Farber Cancer Institute
Boston, MA · Rochester, MN
RecruitingPhase 1NCT07216105
FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors
Sponsor: Fate Therapeutics
La Jolla, CA · Los Angeles, CA · Minneapolis, MN · +2 more sites
RecruitingPhase 1NCT06582017
Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma
Sponsor: Nammi Therapeutics Inc
Los Angeles, CA · +7 more sites
RecruitingPhase 1NCT06949410
HER2 Vaccine for Locally Advanced Breast Cancer
Sponsor: Pravin T.P Kaumaya
Indianapolis, IN
RecruitingPhase 1NCT07660055
Study of [177Lu]Lu-DWJ155 and [68Ga]Ga-DWJ155 in Patients With Solid Tumors
Sponsor: Novartis Pharmaceuticals
Omaha, NE
RecruitingPhase 1NCT07182149
A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors
Sponsor: Normunity AccelCo, Inc.
Denver, CO · New Haven, CT · Washington D.C., DC · +15 more sites
RecruitingPhase 1NCT06242470
A Study of MGC026 in Participants With Advanced Solid Tumors
Sponsor: MacroGenics
Los Angeles, CA · Grand Rapids, MI · Lake Success, NY · +4 more sites
RecruitingPhase 1NCT06910657
IDOV-Immune for Advanced Solid Tumors
Sponsor: ViroMissile, Inc.
St Louis, MO · Houston, TX · San Antonio, TX
RecruitingPhase 1NCT06562192
Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
Sponsor: Novartis Pharmaceuticals
Birmingham, AL · Los Angeles, CA · Palo Alto, CA · +6 more sites
RecruitingPhase 1NCT06347068
Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells
Sponsor: UNC Lineberger Comprehensive Cancer Center
Chapel Hill, NC
RecruitingPhase 1NCT06545942
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
Sponsor: MOMA Therapeutics
Goodyear, AZ · La Jolla, CA · San Francisco, CA · +9 more sites
RecruitingPhase 1NCT05098210
Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer
Sponsor: Fred Hutchinson Cancer Center
Seattle, WA
RecruitingPhase 1NCT07318805
A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors
Sponsor: Pfizer
Duarte, CA · Grand Rapids, MI · Long Island City, NY · +10 more sites
RecruitingPhase 1NCT07524322
Study of RGT-490 in Patients With PIK3CA-Mutated Advanced Solid Tumors
Sponsor: Regor Pharmaceuticals Inc.
Los Angeles, CA · Houston, TX · +2 more sites
RecruitingPhase 1NCT04389632
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
Sponsor: Seagen, a wholly owned subsidiary of Pfizer
Anchorage, AK · Fayetteville, AR · Rogers, AR · +103 more sites
RecruitingPhase 1NCT07046923
A Study of LY4175408 in Participants With Advanced Cancer
Sponsor: Eli Lilly and Company
Stanford, CA · Orlando, FL · Sarasota, FL · +12 more sites
RecruitingPhase 1NCT07540572
A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors
Sponsor: IDEAYA Biosciences
Plantation, FL · East Brunswick, NJ · Lake Success, NY · +8 more sites
RecruitingPhase 1NCT05768932
BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia
Sponsor: SillaJen, Inc.
New Haven, CT · Coral Gables, FL · Atlanta, GA · +8 more sites
RecruitingPhase 1NCT05076760
MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors
Sponsor: Memgen, Inc.
Tampa, FL · Durham, NC
RecruitingPhase 1NCT05283330
Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
Sponsor: Orano Med Theranostics, SAS
Chicago, IL · Iowa City, IA · Lexington, KY · +5 more sites
RecruitingPhase 1NCT06678269
A Study of Abemaciclib and Radiation Therapy in People With Metastatic Breast Cancer
Sponsor: Memorial Sloan Kettering Cancer Center
Basking Ridge, NJ · Middletown, NJ · Montvale, NJ · +4 more sites
RecruitingPhase 1NCT05989347
Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant Therapy
Sponsor: Yale University
New Haven, CT
RecruitingPhase 1NCT07424547
Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors
Sponsor: Conjupro Biotherapeutics, Inc.
Plantation, FL · Austin, TX · +2 more sites
RecruitingPhase 1NCT02926690
Safety Study of MELK Inhibitor to Treat Patients With Advanced Breast Cancer and Triple Negative Breast Cancer
Sponsor: OncoTherapy Science, Inc.
Norwalk, CT · Atlanta, GA · Honolulu, HI · +5 more sites
RecruitingPhase 1NCT07190469
PQ203 in Advanced Malignant Tumors Including Triple Negative Breast Cancer
Sponsor: ProteinQure Inc.
Houston, TX · San Antonio, TX · West Valley City, UT
RecruitingPhase 1NCT06778863
A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
Sponsor: Clasp Therapeutics, Inc.
Scottsdale, AZ · Tucson, AZ · Los Angeles, CA · +18 more sites
RecruitingPhase 1NCT03740256
Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors
Sponsor: Baylor College of Medicine
Houston, TX
Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.