Phase 1 Obesity clinical trials

35 recruiting Phase 1 obesity studies in the US. What trial phases mean

Other phases

RecruitingPhase 1NCT07868354

A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Tirzepatide Medication

Sponsor: Novo Nordisk A/S

Glendale, CA · Baltimore, MD

RecruitingPhase 1NCT06414096

Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome

Sponsor: University of Colorado, Denver

Aurora, CO

RecruitingPhase 1NCT07511205

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.

Sponsor: AstraZeneca

Glendale, CA · Brooklyn, MD

RecruitingPhase 1NCT07808073

A Study of LY4329090 in Participants With Obesity or Overweight Who Are Otherwise Healthy

Sponsor: Eli Lilly and Company

Daytona Beach, FL · Dallas, TX

RecruitingPhase 1NCT06562907

Study of GS-4571 in Healthy Participants, Nondiabetic Obese Participants, and Nonobese Participants With Type 2 Diabetes Mellitus (T2DM)

Sponsor: Gilead Sciences

Miami, FL · San Antonio, TX · Salt Lake City, UT

RecruitingPhase 1NCT07675590

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Orally Administered TIX100 in Healthy Subjects

Sponsor: TIXiMED, Inc.

Chula Vista, CA

RecruitingPhase 1NCT07793929

A Study to Evaluate the Impact of Renal Impairment on the Pharmacokinetics (PK) of Ribupatide

Sponsor: Kailera

Orlando, FL · San Antonio, TX

RecruitingPhase 1NCT07846033

A Phase 1 Study of VK3019 in Overweight and Obese Adults Without Comorbidities

Sponsor: Viking Therapeutics, Inc.

Lake Forest, CA

RecruitingPhase 1NCT07594093

Safety and Drug Concentrations of REGN20934 in Adults With Overweight or Obesity

Sponsor: Regeneron Pharmaceuticals

Glendale, CA

RecruitingPhase 1NCT07842640

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC35 Injection in Participants With Obesity or Overweight

Sponsor: Ascletis Pharma (China) Co., Limited

Baltimore, MD

RecruitingPhase 1NCT07838740

A Phase 1 Study of VK2735 in Obese Adults Without Comorbidities

Sponsor: Viking Therapeutics, Inc.

Lake Forest, CA · Miami, FL

RecruitingPhase 1NCT07731139

A Study to Learn How Different Amounts of the Study Medicine Called PF-08642534 Are Tolerated and Act in the Body of People Who Have Obesity

Sponsor: Pfizer

Lake Forest, CA

RecruitingPhase 1NCT07723833

A Study to Investigate the Relative Bioavailability and Safety of Different Oral Formulations of Elecoglipron in Healthy Participants

Sponsor: AstraZeneca

Glendale, CA · Brooklyn, MD

RecruitingPhase 1NCT07778524

Alpelisib Challenge Test (ACT)

Sponsor: Columbia University

New York, NY

RecruitingPhase 1NCT07738614

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight

Sponsor: Eli Lilly and Company

San Antonio, TX

RecruitingPhase 1NCT07710768

A Research Study on How UBT251 Affects Levels of Midazolam, Caffeine and Warfarin in the Blood of Participants With Excess Body Weight

Sponsor: Novo Nordisk A/S

Cypress, CA

RecruitingPhase 1NCT07291232

A Study of ABBV-295 Subcutaneous Injections to Assess Adverse Events and Pharmacokinetics in Adult Participants With Obesity

Sponsor: AbbVie

Anaheim, CA · Grayslake, IL

RecruitingPhase 1NCT07673900

Semaglutide Delivered Epi-Intradermally by Microarray Patch (VX-201) Versus Subcutaneous Administration in Healthy Overweight and Obese Participants

Sponsor: Terrestrial Bio, Inc.

Tempe, AZ

RecruitingPhase 1NCT07437079

A Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or Obesity

Sponsor: Novo Nordisk A/S

Lenexa, KS

RecruitingPhase 1NCT05071898

Pharmacogenetics of Response to GLP1R Agonists

Sponsor: University of Maryland, Baltimore

Lancaster, PA

RecruitingPhase 1NCT07225816

Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)

Sponsor: Novo Nordisk A/S

Cypress, CA

RecruitingPhase 1NCT06575738

Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents

Sponsor: University of Colorado, Denver

Aurora, CO

RecruitingPhase 1NCT07403604

Effect of Insulin Lowering on Lipogenesis

Sponsor: Columbia University

New York, NY

RecruitingPhase 1NCT04903223

Liver Adiposity Effects on Pediatric Statin

Sponsor: Children's Mercy Hospital Kansas City

Kansas City, MO

RecruitingPhase 1NCT07652047

A Study to Evaluate the Safety and Tolerability of Different Doses of CX11 Tablets

Sponsor: Corxel Pharmaceuticals

Las Vegas, NV · Austin, TX

RecruitingPhase 1NCT07142707

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity

Sponsor: MBX Biosciences

Doral, FL · Lexington, KY · Kansas City, MO · +1 more sites

RecruitingPhase 1NCT02646475

Metabolic Effects of Angiotensin-(1-7)

Sponsor: Vanderbilt University

Nashville, TN

RecruitingPhase 1NCT07219589

A Single and Multiple Ascending Dose Study of HM17321 in Healthy and Obese Participants

Sponsor: Hanmi Pharmaceutical Company Limited

Cincinnati, OH

RecruitingPhase 1NCT06252220

First in Human Study in Subjects With Obesity, But Otherwise Healthy

Sponsor: NeuroBo Pharmaceuticals Inc.

Miami, FL

RecruitingPhase 1NCT07465965

A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults

Sponsor: Shanghai World Leader Pharmaceutical Co., Ltd.

Secaucus, NJ

RecruitingPhase 1NCT05542407

ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer

Sponsor: UNC Lineberger Comprehensive Cancer Center

Chapel Hill, NC

RecruitingPhase 1NCT05584631

IVIG vs SCIG in CIDP

Sponsor: Rutgers, The State University of New Jersey

New Brunswick, NJ

RecruitingPhase 1NCT04934228

Mitigating the Pro-inflammatory Phenotype of Obesity

Sponsor: University of Kansas Medical Center

Kansas City, KS

Not yet recruitingPhase 1NCT07876531

A Study to Learn How Different Forms of the Study Medicine Called Berobenatide is Taken up Into the Blood in Adults With Overweight or Obesity

Sponsor: Pfizer

Anaheim, CA

Not yet recruitingPhase 1NCT07772960

Semaglutide Dose Effects on Metabolic and Stress Hormone, Craving and Alcohol Use Outcomes

Sponsor: Yale University

New Haven, CT

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.